Background/Aims: Vitamin D deficiency is common in children with neurodisabilities. Oral vitamin D3 may not be absorbed appropriately due to dysphagia and tube feeding. The aim of this study was to compare efficacy of vitamin D3 buccal spray with that of oral drops. Methods: Twenty-four children with neurodisabilities (5–17 years) and vitamin D deficiency (25(OH)D ≤20 ng/mL) were randomized to receive vitamin D3 buccal spray 800 IU/daily (n = 12) or oral drops 750 IU/daily (n = 12) for 3 months during winter. Results: Both groups had a significant increase in 25(OH)D (z = 150; p < 0.0001). The differences between baseline and final parathyroid hormone measurements did not reach significance in both groups. Markers of bone formation and resorption did not change significantly in both groups. The satisfaction with the formulation was significantly higher in the patients using spray. Conclusion: Vitamin D3 supplementation with buccal spray and oral drops are equally effective in short-term treatment of vitamin D deficiency in children with neurodisabilities. Buccal spray may be more acceptable by the patients.

Short-Term Vitamin D3 Supplementation in Children with Neurodisabilities : Comparison of Two Delivery Methods / F.M.C. Penagini, B. Borsani, K. Maruca, V. Giosia, S. Bova, M. Mastrangelo, G..V. Zuccotti, S. Mora. - In: HORMONE RESEARCH IN PAEDIATRICS. - ISSN 1663-2818. - 88:3-4(2017 Oct), pp. 281-284.

Short-Term Vitamin D3 Supplementation in Children with Neurodisabilities : Comparison of Two Delivery Methods

F.M.C. Penagini;B. Borsani;V. Giosia;G..V. Zuccotti;
2017

Abstract

Background/Aims: Vitamin D deficiency is common in children with neurodisabilities. Oral vitamin D3 may not be absorbed appropriately due to dysphagia and tube feeding. The aim of this study was to compare efficacy of vitamin D3 buccal spray with that of oral drops. Methods: Twenty-four children with neurodisabilities (5–17 years) and vitamin D deficiency (25(OH)D ≤20 ng/mL) were randomized to receive vitamin D3 buccal spray 800 IU/daily (n = 12) or oral drops 750 IU/daily (n = 12) for 3 months during winter. Results: Both groups had a significant increase in 25(OH)D (z = 150; p < 0.0001). The differences between baseline and final parathyroid hormone measurements did not reach significance in both groups. Markers of bone formation and resorption did not change significantly in both groups. The satisfaction with the formulation was significantly higher in the patients using spray. Conclusion: Vitamin D3 supplementation with buccal spray and oral drops are equally effective in short-term treatment of vitamin D deficiency in children with neurodisabilities. Buccal spray may be more acceptable by the patients.
neurodisabilities; children; vitamin d deficiency; buccal spray; oral drops
Settore MED/38 - Pediatria Generale e Specialistica
Settore MED/13 - Endocrinologia
ott-2017
12-set-2017
Article (author)
File in questo prodotto:
File Dimensione Formato  
vitamin D.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 160.32 kB
Formato Adobe PDF
160.32 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/527752
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 7
social impact