This paper reports on synthesis, acid-base properties and pH-dependent structuring in water of D-, L- and D,L-ARGO7, bioinspired polymers obtained by polyaddition of the corresponding arginine stereoisomers with N,N'-methylenebis(acrylamide). The circular dichroism spectra of D- and L-ARGO7 showed a peak at 228 nm and quickly and reversibly responded to pH changes, but were nearly unaffected by temperature, ionic strength, and denaturating agents. Theoretical modeling studies of L-ARGO7 showed that it assumed a folded structure. Intramolecular interactions led to transoid arrangements of the main chain reminiscent of the protein hairpin motif. Torsion angles showed a quite similar distribution at pH 6 and 14 consistent with the similarity of the CD spectra from pH 6 upward.
Self-Ordering Secondary Structure of D - And L -Arginine-Derived Polyamidoamino Acids / A.G. Manfredi, N. Mauro, A. Terenzi, J. Alongi, F. Lazzari, F. Ganazzoli, G. Raffaini, E. Ranucci, P. Ferruti. - In: ACS MACRO LETTERS. - ISSN 2161-1653. - 6:9(2017 Aug 21), pp. 987-991. [10.1021/acsmacrolett.7b00492]
Self-Ordering Secondary Structure of D - And L -Arginine-Derived Polyamidoamino Acids
A.G. ManfrediPrimo
;J. Alongi;F. Lazzari;E. RanucciPenultimo
;P. FerrutiUltimo
2017
Abstract
This paper reports on synthesis, acid-base properties and pH-dependent structuring in water of D-, L- and D,L-ARGO7, bioinspired polymers obtained by polyaddition of the corresponding arginine stereoisomers with N,N'-methylenebis(acrylamide). The circular dichroism spectra of D- and L-ARGO7 showed a peak at 228 nm and quickly and reversibly responded to pH changes, but were nearly unaffected by temperature, ionic strength, and denaturating agents. Theoretical modeling studies of L-ARGO7 showed that it assumed a folded structure. Intramolecular interactions led to transoid arrangements of the main chain reminiscent of the protein hairpin motif. Torsion angles showed a quite similar distribution at pH 6 and 14 consistent with the similarity of the CD spectra from pH 6 upward.File | Dimensione | Formato | |
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acsmacrolett.pdf
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Tipologia:
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