BACKGROUND: The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) released in 2007 eight recommendations for cancer prevention on body fatness, diet and physical activity. Our aim is to evaluate the relation between adherence to these recommendations and colorectal cancer (CRC) risk. METHODS: We pooled data from two Italian case-control studies including overall 2419 patients with CRC and 4723 controls. Adherence to the WCRF/AICR guidelines was summarised through a score incorporating seven of the WCRF/AICR recommendations, with higher scores indicating higher adherence to the guidelines. Odds ratios (ORs) of colorectal cancer were estimated using multiple logistic regression models. RESULTS: Higher adherence to the WCRF/AICR recommendations was associated with a significantly reduced CRC risk (OR 0.67, 95% confidence interval, CI, 0.56-0.80 for a score ≥5 versus <3.5), with a significant trend of decreasing risk for increasing adherence (p < 0.001). Consistent results were found for colon (OR 0.67) and rectal cancer (OR 0.67). Inverse associations were observed with the diet-specific WCRF/AICR score (OR 0.71, 95% CI, 0.61-0.84 for ≥3.5 versus <2.5 points) and with specific recommendations on body fatness (OR 0.82, 95% CI, 0.70-0.97), physical activity (OR 0.86, 95% CI, 0.75-1.00), foods and drinks that promote weight gain (OR 0.70, 95% CI, 0.56-0.89), foods of plant origin (OR 0.56, 95% CI, 0.42-0.76), limiting alcohol (OR 0.87, 95% CI, 0.77-0.99) and salt intake (OR 0.63, 95% CI, 0.48-0.84). CONCLUSION: Our study indicated that adherence to the WCRF/AICR recommendations is inversely related to CRC risk.
Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and colorectal cancer risk / F. Turati, F. Bravi, M. Di Maso, C. Bosetti, J. Polesel, D. Serraino, M. Dalmartello, A. Giacosa, M. Montella, A. Tavani, E. Negri, C. La Vecchia. - In: EUROPEAN JOURNAL OF CANCER. - ISSN 0959-8049. - 85(2017 Nov), pp. 86-94.
|Titolo:||Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and colorectal cancer risk|
TURATI, FEDERICA (Corresponding)
BRAVI, FRANCESCA (Secondo)
NEGRI, EVA VANNA LORENZA (Penultimo)
|Parole Chiave:||Case-control; Colorectal neoplasms; Diet; Nutrition policy; Prevention; Oncology; Cancer Research|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||nov-2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ejca.2017.08.015|
|Appare nelle tipologie:||01 - Articolo su periodico|