Introduction. Endocarditis is a rare complication of bacteraemia due to Listeria monocytogenes and is characterized by a high fatality rate (37–50 %). Recurrent infection by Listeria monocytogenes occurs even more rarely. Case presentation. We report a case of recurrent Listeria monocytogenes infection that resulted in severe endocarditis in a 66-year-old patient with an aortic valve prosthesis. Relapse was confirmed by pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST). Conclusion. Our case highlights that the molecular subtyping approach is an important tool for the detection of microbial reinfections and for the support of clinical diagnosis.

Molecular evidence of Listeria monocytogenes infection relapse in a severe case of endocarditis / G. Ciceri, M. Gori, S. Bianchi, G. Corrado, P. Panisi, A. Papa, E. Tanzi, M..M. Pontello. - In: JMM CASE REPORTS. - ISSN 2053-3721. - 4:9(2017 Sep 18), pp. e005115.1-e005115.4. [10.1099/jmmcr.0.005115]

Molecular evidence of Listeria monocytogenes infection relapse in a severe case of endocarditis

G. Ciceri
Primo
;
M. Gori
Secondo
;
S. Bianchi;A. Papa;E. Tanzi
Penultimo
;
M..M. Pontello
Ultimo
2017-09-18

Abstract

Introduction. Endocarditis is a rare complication of bacteraemia due to Listeria monocytogenes and is characterized by a high fatality rate (37–50 %). Recurrent infection by Listeria monocytogenes occurs even more rarely. Case presentation. We report a case of recurrent Listeria monocytogenes infection that resulted in severe endocarditis in a 66-year-old patient with an aortic valve prosthesis. Relapse was confirmed by pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST). Conclusion. Our case highlights that the molecular subtyping approach is an important tool for the detection of microbial reinfections and for the support of clinical diagnosis.
molecular subtyping; Listeria monocytogenes; invasive listeriosis; surveillance; endocarditis; relapse
Settore MED/42 - Igiene Generale e Applicata
Settore MED/07 - Microbiologia e Microbiologia Clinica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/525554
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