Genome rearrangements are a hallmark of human genomic disorders and occur largely through recombination mechanisms. In this issue, Lee et al. (2007) show that the complex nonrecurrent rearrangements observed in the dysmyelinating disorder Pelizaeus-Merzbacher disease (PMD) are likely to be caused by a replication mechanism involving template switching.
Template switching: from replication fork repair to genome rearrangements / D. Branzei, M. Foiani. - In: CELL. - ISSN 0092-8674. - 131:7(2007), pp. 1228-1230.
Template switching: from replication fork repair to genome rearrangements
M. FoianiUltimo
2007
Abstract
Genome rearrangements are a hallmark of human genomic disorders and occur largely through recombination mechanisms. In this issue, Lee et al. (2007) show that the complex nonrecurrent rearrangements observed in the dysmyelinating disorder Pelizaeus-Merzbacher disease (PMD) are likely to be caused by a replication mechanism involving template switching.File in questo prodotto:
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