Genome rearrangements are a hallmark of human genomic disorders and occur largely through recombination mechanisms. In this issue, Lee et al. (2007) show that the complex nonrecurrent rearrangements observed in the dysmyelinating disorder Pelizaeus-Merzbacher disease (PMD) are likely to be caused by a replication mechanism involving template switching.

Template switching: from replication fork repair to genome rearrangements / D. Branzei, M. Foiani. - In: CELL. - ISSN 0092-8674. - 131:7(2007), pp. 1228-1230.

Template switching: from replication fork repair to genome rearrangements

M. Foiani
Ultimo
2007

Abstract

Genome rearrangements are a hallmark of human genomic disorders and occur largely through recombination mechanisms. In this issue, Lee et al. (2007) show that the complex nonrecurrent rearrangements observed in the dysmyelinating disorder Pelizaeus-Merzbacher disease (PMD) are likely to be caused by a replication mechanism involving template switching.
Settore BIO/11 - Biologia Molecolare
2007
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/52524
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