Aim: We investigate MAdCAM-1 as a reliable target to detect active bowel inflammation for selective noninvasive nanodiagnostics. Materials & methods: We coupled anti-MAdCAM-1 antibodies to manganese oxide nanoparticles, and analyzed nanoconjugate biodistribution and safety in murine model of inflammatory bowel disease by imaging and histology. Results: Nanoparticles were stable and nontoxic. Upon administration in colitic mice, anti-MAdCAM-1 functionalized nanoparticles preferentially localized in the inflamed bowel, whereas untargeted nanoparticles were more rapidly washed out. Nanoparticles did not induce lesions in nontarget organs. Conclusion: Anti-MAdCAM-1 functionalized nanoparticles detected active bowel inflammation foci, accurately following MAdCAM-1 expression pattern. These nanoconjugates could be a promising noninvasive imaging system for an early and accurate follow-up in patients affected by acute colitis.
Nano-targeting of mucosal addressin cell adhesion molecule-1 identifies bowel inflammation foci in murine model / M. Truffi, M. Colombo, J. Penaranda Avila, L. Sorrentino, F. Colombo, M. Monieri, V. Collico, P. Zerbi, E. Longhi, R. Allevi, D. Prosperi, F. Corsi. - In: NANOMEDICINE. - ISSN 1743-5889. - 12:13(2017 Jul), pp. 1547-1560.
Titolo: | Nano-targeting of mucosal addressin cell adhesion molecule-1 identifies bowel inflammation foci in murine model |
Autori: | TRUFFI, MARTA (Primo) CORSI, FABIO RUGGERO MARIA (Ultimo) (Corresponding) |
Parole Chiave: | imaging; inflammatory bowel disease; MAdCAM-1; manganese oxide nanoparticles |
Settore Scientifico Disciplinare: | Settore MED/12 - Gastroenterologia Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica Settore BIO/10 - Biochimica Settore BIO/13 - Biologia Applicata Settore MED/18 - Chirurgia Generale Settore MED/08 - Anatomia Patologica |
Data di pubblicazione: | lug-2017 |
Rivista: | |
Tipologia: | Article (author) |
Data ahead of print / Data di stampa: | 16-giu-2017 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.2217/nnm-2017-0004 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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