The functionalization of colloidal nanoparticles with short peptides often fails in achieving satisfactory targeting efficiency and selectivity toward receptor-specific human cells. Here, we show that an optimized passivation of gold nanoparticle surface with a mixed self-assembled monolayer, including a targeting ligand, a fluorescent dye, and an intercalating short PEG derivative, led to a very stable, nontoxic, and efficient nanoconjugate for targeting urokinase plasminogen activator receptor-positive breast cancer cells.

Development of U11-functionalized gold nanoparticles for selective targeting of urokinase plasminogen activator receptor-positive breast cancer cells / S. Avvakumova, E. Galbiati, L. Pandolfi, S. Mazzucchelli, M. Cassani, A. Gori, R. Longhi, D. Prosperi. - In: BIOCONJUGATE CHEMISTRY. - ISSN 1043-1802. - 25:8(2014 Aug), pp. 1381-1386.

Development of U11-functionalized gold nanoparticles for selective targeting of urokinase plasminogen activator receptor-positive breast cancer cells

S. Mazzucchelli;A. Gori;
2014-08

Abstract

The functionalization of colloidal nanoparticles with short peptides often fails in achieving satisfactory targeting efficiency and selectivity toward receptor-specific human cells. Here, we show that an optimized passivation of gold nanoparticle surface with a mixed self-assembled monolayer, including a targeting ligand, a fluorescent dye, and an intercalating short PEG derivative, led to a very stable, nontoxic, and efficient nanoconjugate for targeting urokinase plasminogen activator receptor-positive breast cancer cells.
amino acid sequence; breast neoplasms; cell line, tumor; drug design; fluorescent dyes; gold; humans; ligands; metal nanoparticles; models, molecular; molecular conformation; oligopeptides; polyethylene glycols; receptors, urokinase plasminogen activator; substrate specificity; molecular targeted therapy; biotechnology; bioengineering; biomedical engineering; pharmacology; organic chemistry
Settore BIO/10 - Biochimica
Settore BIO/13 - Biologia Applicata
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/524911
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