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Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which complicates the care and treatment of individual patients. The protocol of the ongoing International GBS Outcome Study (IGOS), a prospective, observational, multicenter cohort study that aims to identify the clinical and biological determinants and predictors of disease onset, subtype, course and outcome of GBS is presented here. Patients fulfilling the diagnostic criteria for GBS, regardless of age, disease severity, variant forms, or treatment, can participate if included within 2 weeks after onset of weakness. Information about demography, preceding infections, clinical features, diagnostic findings, treatment, course, and outcome is collected. In addition, cerebrospinal fluid and serial blood samples for serum and DNA is collected at standard time points. The original aim was to include at least 1,000 patients with a follow-up of 1-3 years. Data are collected via a web-based data entry system and stored anonymously. IGOS started in May 2012 and by January 2017 included more than 1,400 participants from 143 active centers in 19 countries across 5 continents. The IGOS data/biobank is available for research projects conducted by expertise groups focusing on specific topics including epidemiology, diagnostic criteria, clinimetrics, electrophysiology, antecedent events, antibodies, genetics, prognostic modeling, treatment effects, and long-term outcome of GBS. The IGOS will help to standardize the international collection of data and biosamples for future research of GBS.
International Guillain-Barré Syndrome Outcome Study : protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome / B.C. Jacobs, B. van den Berg, C. Verboon, G. Chavada, D.R. Cornblath, K.C. Gorson, T. Harbo, H. Hartung, R.A..C. Hughes, S. Kusunoki, P.A. van Doorn, H.J. Willison, B.C. Jacobs, R.A.C. Hughes, D.R. Cornblath, K.C. Gorson, H.P. Hartung, S. Kusunoki, P.A. van Doorn, H.J. Willison, M. van Woerkom, B. van den Berg, C. Verboon, J. Roodbol, B.C. Jacobs, R.C. Reisin, S.W. Reddel, Z. Islam, B. Islam, Q.D. Mohammad, P. van den Bergh, T.E. Feasby, Y.Z. Wang, T. Harbo, Y. Péréon, H.P. Hartung, H.C. Lehmann, E. Dardiotis, E. Nobile-Orazio, S. Kusunoki, N. Shahrizaila, B.C. Jacobs, B. van den Berg, C. Verboon, K. Bateman, I. Illa, L.A. Querol, S.T. Hsieh, H.J. Willison, G. Chavada, A. Davidson, K.C. Gorson, J.M. Addington, S. Ajroud-Driss, H. Andersen, G. Antonini, S. Attarian, U. Badrising, F.A. Barroso, L. Benedetti, A. Beronio, M. Bianco, D. Binda, C. Briani, J. Bã¼rmann, I.R. Bella, T.E. Bertorini, R. Bhavaraju-Sanka, T.H. Brannagan, M. Busby, S. Butterworth, M. Campagnolo, C. Casasnovas, G. Cavaletti, C.S. Chao, S. Chen, S. Chetty, K.G. Claeys, J.A. Cohen, M.E. Conti, J.S. Cosgrove, M.C. Dalakas, M.M. Dimachkie, U. Dillmann, C. Domínguez-González, K. Doppler, C. Dornonville de la Cour, A. Echaniz-Laguna, F. Eftimov, C.G. Faber, R. Fazio, C. Fokke, T. Fujioka, E.A. Fulgenzi, G. Galassi, T. Garcia, M. Garnero, M.P.J. Garssen, C.J. Gijsbers, J.M. Gilchrist, H.J. Gilhuis, J.M. Goldstein, N. Goyal, V. Granit, A. Grapperon, G.Gutiérrez Gutiérrez, L. Gutmann, R.D.M. Hadden, J.V. Holbech, J.K.L. Holt, C. Homedes Pedret, M. Htut, K. Jellema, I. Jericó-Pascual, K. Kaida, S. Karafiath, H.D. Katzberg, L. Kiers, B.C. Kieseier, K. Kimpinski, R.P. Kleyweg, N. Kokubun, N.A. Kolb, K. Kuitwaard, S. Kuwabara, J.Y. Kwan, S.S. Ladha, L. Landschoff Lassen, V. Lawson, D. Ledingham, L. León Cejas, C.A. Luciano, S.T. Lucy, M.P.T. Lunn, A. Magot, H. Manji, C. Marchesoni, G.A.M. Marfia, C. Márquez-Infante, E. Martinez Hernandez, G. Mataluni, M. Mattiazi, C.J. Mcdermott, G.D. Meekins, J. Miller, M.S. Monges, M.C.J. Montero, G. Morís de la Tassa, C. Nascimbene, C. Neumann, R.J. Nowak, P. Orizaola Balaguer, M. Osei-Bonsu, E.B.L. Pan, J. Pardo Fernandez, M. Pasnoor, M.T. Pulley, Y.A. Rajabally, S. Rinaldi, C. Ritter, R.C. Roberts, I. Rojas-Marcos, S.A. Rudnicki, G.M. Sachs, J.P.A. Samijn, L. Santoro, D.S. Saperstein, A. Savransky, H. Schneider, A. Schenone, M.J. Sedano Tous, Y. Sekiguchi, K.A. Sheikh, N.J. Silvestri, S.H. Sindrup, C.L. Sommer, B. Stein, A.M. Stino, A. Spyropoulos, J. Srinivasan, H. Suzuki, S.W. Taylor, H. Tankisi, D. Tigner, P.T. Twydell, F. Valzania, P. van Damme, A.J. van der Kooi, G.W. van Dijk, T. van der Ree, R. van Koningsveld, J.D. Varrato, F.H. Vermeij, J.J.G.M. Verschuuren, L.H. Visser, M.V. Vytopil, W. Waheed, M. Wilken, C. Wilkerson, P.W. Wirtz, Y. Yamagishi, E.M. Yiu, L. Zhou, S. Zivkovic. - In: JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM. - ISSN 1085-9489. - 22:2(2017), pp. 68-76.
International Guillain-Barré Syndrome Outcome Study : protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome
B. C. Jacobs;B. van den Berg;C. Verboon;G. Chavada;D. R. Cornblath;K. C. Gorson;T. Harbo;H. Hartung;R. A. . C. Hughes;S. Kusunoki;P. A. van Doorn;H. J. Willison;B. C. Jacobs;R. A. C. Hughes;D. R. Cornblath;K. C. Gorson;H. P. Hartung;S. Kusunoki;P. A. van Doorn;H. J. Willison;M. van Woerkom;B. van den Berg;C. Verboon;J. Roodbol;B. C. Jacobs;R. C. Reisin;S. W. Reddel;Z. Islam;B. Islam;Q. D. Mohammad;P. van den Bergh;T. E. Feasby;Y. Z. Wang;T. Harbo;Y. Péréon;H. P. Hartung;H. C. Lehmann;E. Dardiotis;E. Nobile-Orazio;S. Kusunoki;N. Shahrizaila;B. C. Jacobs;B. van den Berg;C. Verboon;K. Bateman;I. Illa;L. A. Querol;S. T. Hsieh;H. J. Willison;G. Chavada;A. Davidson;K. C. Gorson;J. M. Addington;S. Ajroud Driss;H. Andersen;G. Antonini;S. Attarian;U. Badrising;F. A. Barroso;L. Benedetti;A. Beronio;M. Bianco;D. Binda;C. Briani;J. Bã¼rmann;I. R. Bella;T. E. Bertorini;R. Bhavaraju Sanka;T. H. Brannagan;M. Busby;S. Butterworth;M. Campagnolo;C. Casasnovas;G. Cavaletti;C. S. Chao;S. Chen;S. Chetty;K. G. Claeys;J. A. Cohen;M. E. Conti;J. S. Cosgrove;M. C. Dalakas;M. M. Dimachkie;U. Dillmann;C. Domínguez González;K. Doppler;C. Dornonville de la Cour;A. Echaniz Laguna;F. Eftimov;C. G. Faber;R. Fazio;C. Fokke;T. Fujioka;E. A. Fulgenzi;G. Galassi;T. Garcia;M. Garnero;M. P. J. Garssen;C. J. Gijsbers;J. M. Gilchrist;H. J. Gilhuis;J. M. Goldstein;N. Goyal;V. Granit;A. Grapperon;G. Gutiérrez Gutiérrez;L. Gutmann;R. D. M. Hadden;J. V. Holbech;J. K. L. Holt;C. Homedes Pedret;M. Htut;K. Jellema;I. Jericó Pascual;K. Kaida;S. Karafiath;H. D. Katzberg;L. Kiers;B. C. Kieseier;K. Kimpinski;R. P. Kleyweg;N. Kokubun;N. A. Kolb;K. Kuitwaard;S. Kuwabara;J. Y. Kwan;S. S. Ladha;L. Landschoff Lassen;V. Lawson;D. Ledingham;L. León Cejas;C. A. Luciano;S. T. Lucy;M. P. T. Lunn;A. Magot;H. Manji;C. Marchesoni;G. A. M. Marfia;C. Márquez Infante;E. Martinez Hernandez;G. Mataluni;M. Mattiazi;C. J. Mcdermott;G. D. Meekins;J. Miller;M. S. Monges;M. C. J. Montero;G. Morís de la Tassa;C. Nascimbene;C. Neumann;R. J. Nowak;P. Orizaola Balaguer;M. Osei Bonsu;E. B. L. Pan;J. Pardo Fernandez;M. Pasnoor;M. T. Pulley;Y. A. Rajabally;S. Rinaldi;C. Ritter;R. C. Roberts;I. Rojas Marcos;S. A. Rudnicki;G. M. Sachs;J. P. A. Samijn;L. Santoro;D. S. Saperstein;A. Savransky;H. Schneider;A. Schenone;M. J. Sedano Tous;Y. Sekiguchi;K. A. Sheikh;N. J. Silvestri;S. H. Sindrup;C. L. Sommer;B. Stein;A. M. Stino;A. Spyropoulos;J. Srinivasan;H. Suzuki;S. W. Taylor;H. Tankisi;D. Tigner;P. T. Twydell;F. Valzania;P. van Damme;A. J. van der Kooi;G. W. van Dijk;T. van der Ree;R. van Koningsveld;J. D. Varrato;F. H. Vermeij;J. J. G. M. Verschuuren;L. H. Visser;M. V. Vytopil;W. Waheed;M. Wilken;C. Wilkerson;P. W. Wirtz;Y. Yamagishi;E. M. Yiu;L. Zhou;S. Zivkovic
2017
Abstract
Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which complicates the care and treatment of individual patients. The protocol of the ongoing International GBS Outcome Study (IGOS), a prospective, observational, multicenter cohort study that aims to identify the clinical and biological determinants and predictors of disease onset, subtype, course and outcome of GBS is presented here. Patients fulfilling the diagnostic criteria for GBS, regardless of age, disease severity, variant forms, or treatment, can participate if included within 2 weeks after onset of weakness. Information about demography, preceding infections, clinical features, diagnostic findings, treatment, course, and outcome is collected. In addition, cerebrospinal fluid and serial blood samples for serum and DNA is collected at standard time points. The original aim was to include at least 1,000 patients with a follow-up of 1-3 years. Data are collected via a web-based data entry system and stored anonymously. IGOS started in May 2012 and by January 2017 included more than 1,400 participants from 143 active centers in 19 countries across 5 continents. The IGOS data/biobank is available for research projects conducted by expertise groups focusing on specific topics including epidemiology, diagnostic criteria, clinimetrics, electrophysiology, antecedent events, antibodies, genetics, prognostic modeling, treatment effects, and long-term outcome of GBS. The IGOS will help to standardize the international collection of data and biosamples for future research of GBS.
International Guillain-Barré Syndrome Outcome Study : protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome / B.C. Jacobs, B. van den Berg, C. Verboon, G. Chavada, D.R. Cornblath, K.C. Gorson, T. Harbo, H. Hartung, R.A..C. Hughes, S. Kusunoki, P.A. van Doorn, H.J. Willison, B.C. Jacobs, R.A.C. Hughes, D.R. Cornblath, K.C. Gorson, H.P. Hartung, S. Kusunoki, P.A. van Doorn, H.J. Willison, M. van Woerkom, B. van den Berg, C. Verboon, J. Roodbol, B.C. Jacobs, R.C. Reisin, S.W. Reddel, Z. Islam, B. Islam, Q.D. Mohammad, P. van den Bergh, T.E. Feasby, Y.Z. Wang, T. Harbo, Y. Péréon, H.P. Hartung, H.C. Lehmann, E. Dardiotis, E. Nobile-Orazio, S. Kusunoki, N. Shahrizaila, B.C. Jacobs, B. van den Berg, C. Verboon, K. Bateman, I. Illa, L.A. Querol, S.T. Hsieh, H.J. Willison, G. Chavada, A. Davidson, K.C. Gorson, J.M. Addington, S. Ajroud-Driss, H. Andersen, G. Antonini, S. Attarian, U. Badrising, F.A. Barroso, L. Benedetti, A. Beronio, M. Bianco, D. Binda, C. Briani, J. Bã¼rmann, I.R. Bella, T.E. Bertorini, R. Bhavaraju-Sanka, T.H. Brannagan, M. Busby, S. Butterworth, M. Campagnolo, C. Casasnovas, G. Cavaletti, C.S. Chao, S. Chen, S. Chetty, K.G. Claeys, J.A. Cohen, M.E. Conti, J.S. Cosgrove, M.C. Dalakas, M.M. Dimachkie, U. Dillmann, C. Domínguez-González, K. Doppler, C. Dornonville de la Cour, A. Echaniz-Laguna, F. Eftimov, C.G. Faber, R. Fazio, C. Fokke, T. Fujioka, E.A. Fulgenzi, G. Galassi, T. Garcia, M. Garnero, M.P.J. Garssen, C.J. Gijsbers, J.M. Gilchrist, H.J. Gilhuis, J.M. Goldstein, N. Goyal, V. Granit, A. Grapperon, G.Gutiérrez Gutiérrez, L. Gutmann, R.D.M. Hadden, J.V. Holbech, J.K.L. Holt, C. Homedes Pedret, M. Htut, K. Jellema, I. Jericó-Pascual, K. Kaida, S. Karafiath, H.D. Katzberg, L. Kiers, B.C. Kieseier, K. Kimpinski, R.P. Kleyweg, N. Kokubun, N.A. Kolb, K. Kuitwaard, S. Kuwabara, J.Y. Kwan, S.S. Ladha, L. Landschoff Lassen, V. Lawson, D. Ledingham, L. León Cejas, C.A. Luciano, S.T. Lucy, M.P.T. Lunn, A. Magot, H. Manji, C. Marchesoni, G.A.M. Marfia, C. Márquez-Infante, E. Martinez Hernandez, G. Mataluni, M. Mattiazi, C.J. Mcdermott, G.D. Meekins, J. Miller, M.S. Monges, M.C.J. Montero, G. Morís de la Tassa, C. Nascimbene, C. Neumann, R.J. Nowak, P. Orizaola Balaguer, M. Osei-Bonsu, E.B.L. Pan, J. Pardo Fernandez, M. Pasnoor, M.T. Pulley, Y.A. Rajabally, S. Rinaldi, C. Ritter, R.C. Roberts, I. Rojas-Marcos, S.A. Rudnicki, G.M. Sachs, J.P.A. Samijn, L. Santoro, D.S. Saperstein, A. Savransky, H. Schneider, A. Schenone, M.J. Sedano Tous, Y. Sekiguchi, K.A. Sheikh, N.J. Silvestri, S.H. Sindrup, C.L. Sommer, B. Stein, A.M. Stino, A. Spyropoulos, J. Srinivasan, H. Suzuki, S.W. Taylor, H. Tankisi, D. Tigner, P.T. Twydell, F. Valzania, P. van Damme, A.J. van der Kooi, G.W. van Dijk, T. van der Ree, R. van Koningsveld, J.D. Varrato, F.H. Vermeij, J.J.G.M. Verschuuren, L.H. Visser, M.V. Vytopil, W. Waheed, M. Wilken, C. Wilkerson, P.W. Wirtz, Y. Yamagishi, E.M. Yiu, L. Zhou, S. Zivkovic. - In: JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM. - ISSN 1085-9489. - 22:2(2017), pp. 68-76.
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B.C. Jacobs, B. van den Berg, C. Verboon, G. Chavada, D.R. Cornblath, K.C. Gorson, T. Harbo, H. Hartung, R.A..C. Hughes, S. Kusunoki, P.A. van Doorn, H.J. Willison, B.C. Jacobs, R.A.C. Hughes, D.R. Cornblath, K.C. Gorson, H.P. Hartung, S. Kusunoki, P.A. van Doorn, H.J. Willison, M. van Woerkom, B. van den Berg, C. Verboon, J. Roodbol, B.C. Jacobs, R.C. Reisin, S.W. Reddel, Z. Islam, B. Islam, Q.D. Mohammad, P. van den Bergh, T.E. Feasby, Y.Z. Wang, T. Harbo, Y. Péréon, H.P. Hartung, H.C. Lehmann, E. Dardiotis, E. Nobile-Orazio, S. Kusunoki, N. Shahrizaila, B.C. Jacobs, B. van den Berg, C. Verboon, K. Bateman, I. Illa, L.A. Querol, S.T. Hsieh, H.J. Willison, G. Chavada, A. Davidson, K.C. Gorson, J.M. Addington, S. Ajroud-Driss, H. Andersen, G. Antonini, S. Attarian, U. Badrising, F.A. Barroso, L. Benedetti, A. Beronio, M. Bianco, D. Binda, C. Briani, J. Bã¼rmann, I.R. Bella, T.E. Bertorini, R. Bhavaraju-Sanka, T.H. Brannagan, M. Busby, S. Butterworth, M. Campagnolo, C. Casasnovas, G. Cavaletti, C.S. Chao, S. Chen, S. Chetty, K.G. Claeys, J.A. Cohen, M.E. Conti, J.S. Cosgrove, M.C. Dalakas, M.M. Dimachkie, U. Dillmann, C. Domínguez-González, K. Doppler, C. Dornonville de la Cour, A. Echaniz-Laguna, F. Eftimov, C.G. Faber, R. Fazio, C. Fokke, T. Fujioka, E.A. Fulgenzi, G. Galassi, T. Garcia, M. Garnero, M.P.J. Garssen, C.J. Gijsbers, J.M. Gilchrist, H.J. Gilhuis, J.M. Goldstein, N. Goyal, V. Granit, A. Grapperon, G.Gutiérrez Gutiérrez, L. Gutmann, R.D.M. Hadden, J.V. Holbech, J.K.L. Holt, C. Homedes Pedret, M. Htut, K. Jellema, I. Jericó-Pascual, K. Kaida, S. Karafiath, H.D. Katzberg, L. Kiers, B.C. Kieseier, K. Kimpinski, R.P. Kleyweg, N. Kokubun, N.A. Kolb, K. Kuitwaard, S. Kuwabara, J.Y. Kwan, S.S. Ladha, L. Landschoff Lassen, V. Lawson, D. Ledingham, L. León Cejas, C.A. Luciano, S.T. Lucy, M.P.T. Lunn, A. Magot, H. Manji, C. Marchesoni, G.A.M. Marfia, C. Márquez-Infante, E. Martinez Hernandez, G. Mataluni, M. Mattiazi, C.J. Mcdermott, G.D. Meekins, J. Miller, M.S. Monges, M.C.J. Montero, G. Morís de la Tassa, C. Nascimbene, C. Neumann, R.J. Nowak, P. Orizaola Balaguer, M. Osei-Bonsu, E.B.L. Pan, J. Pardo Fernandez, M. Pasnoor, M.T. Pulley, Y.A. Rajabally, S. Rinaldi, C. Ritter, R.C. Roberts, I. Rojas-Marcos, S.A. Rudnicki, G.M. Sachs, J.P.A. Samijn, L. Santoro, D.S. Saperstein, A. Savransky, H. Schneider, A. Schenone, M.J. Sedano Tous, Y. Sekiguchi, K.A. Sheikh, N.J. Silvestri, S.H. Sindrup, C.L. Sommer, B. Stein, A.M. Stino, A. Spyropoulos, J. Srinivasan, H. Suzuki, S.W. Taylor, H. Tankisi, D. Tigner, P.T. Twydell, F. Valzania, P. van Damme, A.J. van der Kooi, G.W. van Dijk, T. van der Ree, R. van Koningsveld, J.D. Varrato, F.H. Vermeij, J.J.G.M. Verschuuren, L.H. Visser, M.V. Vytopil, W. Waheed, M. Wilken, C. Wilkerson, P.W. Wirtz, Y. Yamagishi, E.M. Yiu, L. Zhou, S. Zivkovic
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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.