The CORP (COlchicine for Recurrent Pericarditis) trial is a prospective, randomized, double-blind, placebo controlled, multicenter trial to evaluate the efficacy and safety of colchicine (1.0–2.0 mg on the first day, followed by a maintenance dose of 0.5–1.0 mg/day for 6 months) in association with conventional anti-inflammatory therapy for the secondary prevention of recurrence in patients with a first relapse of pericarditis. Patients were excluded if they were having their first episode of acute pericarditis, or their second or subsequent recurrence, or had pericarditis with tuberculous, purulent, or neoplastic causes. The primary study end point was the recurrence rate at 18 months. Secondary end points were symptom persistence after 72 h, remission rate at 1 week, number of recurrences, time to first recurrence, disease-related hospitalizations,cardiac tamponade, and constrictive pericarditis rates.120 patients (60 in the colchicine and 60 in the placebo group) were included in the analysis. The recurrence rate is 24 % in the colchicine group and 55 % in the placebo group (absolute risk reduction 0.31 [95 % CI 0.13–0.46];relative risk reduction 0.56 [0.27–0.73]; number needed to treat 3 [2–7]). Colchicine improves the persistence of symptoms at 72 h (absolute risk reduction 0.30 [95 % IC,0.13–0.45]; relative risk reduction 0.56 [0.27–0.74]). It also reduces the mean number of recurrences, increases the remission rate at 1 week and prolongs the time to subsequent recurrence. Colchicine and placebo groups have similar rates of side effects (7 %) and drug withdrawal (8 vs. 5 %, P = 0.89);no severe side effects occurred in any of the groups. Gastrointestinal intolerance was the main side effect during the study.
Colchicine is safe and effective for secondary prevention of recurrent pericarditis / F. Gianni, M. Solbiati. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - 7:2(2012 Apr), pp. 181-182.
|Titolo:||Colchicine is safe and effective for secondary prevention of recurrent pericarditis|
GIANNI, FRANCESCA (Primo)
SOLBIATI, MONICA (Corresponding)
|Parole Chiave:||colchicine; confidence intervals; double-blind method; female; follow-up studies; humans; male; pericarditis; prospective studies; reference values; safety management; secondary prevention; time factors; treatment outcome; emergency medicine; internal medicine|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
|Data di pubblicazione:||apr-2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s11739-012-0775-z|
|Appare nelle tipologie:||01 - Articolo su periodico|