Is PSA useful in the diagnosis and monitoring of parotid adenocarcinomas?

We report the case of a patient with Androgen's Receptor (AR) and PSA positive parotid adenocarcinoma, who developed skeletal and bone marrow lesions in presence of elevated seric PSA values (142 μg/L). The tumor cells infiltrating the bone marrow were found positive for both AR and PSA, mimicking clinical and immunohistochemical metastases from prostate cancer, which was definitively ruled out. These observations suggest that in salivary gland metastatic AR-positive carcinomas seric PSA evaluation might be useful for the disease monitoring. Androgen deprivation, previously reported as beneficial in a few cases, should be further investigated.