The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal welfare concerns. Here we show that the availability of genome-wide, high-density SNP panels, combined with the typical structure of livestock populations, markedly accelerates the positional identification of genes and mutations that cause inherited defects. We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of these: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle and ichthyosis fetalis in Italian Chianina cattle. Identification of these causative mutations has an immediate translation into breeding practice, allowing marker assisted selection against the defects through avoidance of at-risk matings.

Highly effective SNP-based association mapping and management of recessive defects in livestock / C. Charlier, W. Coppieters, F. Rollin, D. Desmecht, J.S. Agerholm, N. Cambisano, E. Carta, S. Dardano, M. Dive, C. Fasquelle, J.C. Frennet, R. Hanset, X. Hubin, C. Jorgensen, L. Karim, M. Kent, K. Harvey, B.R. Pearce, P. Simon, N. Tama, H. Nie, S. Vandeputte, S. Lien, M. Longeri, M. Fredholm, R. J. Harvey, M. Georges. - In: NATURE GENETICS. - ISSN 1061-4036. - 40:4(2008), pp. 449-454. [10.1038/ng.96]

Highly effective SNP-based association mapping and management of recessive defects in livestock

S. Dardano;M. Longeri;
2008

Abstract

The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal welfare concerns. Here we show that the availability of genome-wide, high-density SNP panels, combined with the typical structure of livestock populations, markedly accelerates the positional identification of genes and mutations that cause inherited defects. We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of these: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle and ichthyosis fetalis in Italian Chianina cattle. Identification of these causative mutations has an immediate translation into breeding practice, allowing marker assisted selection against the defects through avoidance of at-risk matings.
Settore AGR/17 - Zootecnica Generale e Miglioramento Genetico
Article (author)
File in questo prodotto:
File Dimensione Formato  
Charlier_2008_finale.pdf

accesso aperto

Tipologia: Pre-print (manoscritto inviato all'editore)
Dimensione 1.79 MB
Formato Adobe PDF
1.79 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/52309
Citazioni
  • ???jsp.display-item.citation.pmc??? 98
  • Scopus 226
  • ???jsp.display-item.citation.isi??? 205
social impact