The present work concerns an efficient strategy to obtain novel medical devices materials able to inhibit biofilm formation. The new materials were achieved by covalent grafting of p-aminocinnamic or p-aminosalicylic acids on low density polyethylene coupons. The polyethylene surface, previously activated by oxygen plasma treatment, was functionalized using 2-hydroxymethylmetacrylate as linker. The latter was reacted with succinic anhydride affording the carboxylic end useful for the immobilization of the antibiofilm molecules. The modified surface was characterized by scanning electron microscope, X-ray photoelectron spectroscopy, attenuated total reflectance Fourier transform infrared and fluorescence analyses. The antibiofilm activity of the modified materials were tested against Escherichia coli biofilm grown in the Center of Disease Control biofilm reactor. The results revealed that the grafted cinnamic and salicylic acid derivatives reduced biofilm biomass, in comparison with the control, by 73.7 ± 10.7% and 63.4 ± 7.1%, respectively.
Low density polyethylene functionalized with antibiofilm compounds inhibits Escherichia coli cell adhesion / S. Dell'Orto, C. Cattò, F. Villa, F. Forlani, E. Vassallo, M. Morra, F. Cappitelli, S. Villa, A. Gelain. - In: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A. - ISSN 1549-3296. - (2017 Sep 02). [Epub ahead of print] [10.1002/jbm.a.36183]
Low density polyethylene functionalized with antibiofilm compounds inhibits Escherichia coli cell adhesion
S. Dell'OrtoPrimo
;C. CattòSecondo
;F. Villa;F. Forlani;F. Cappitelli;S. VillaPenultimo
;A. GelainUltimo
2017
Abstract
The present work concerns an efficient strategy to obtain novel medical devices materials able to inhibit biofilm formation. The new materials were achieved by covalent grafting of p-aminocinnamic or p-aminosalicylic acids on low density polyethylene coupons. The polyethylene surface, previously activated by oxygen plasma treatment, was functionalized using 2-hydroxymethylmetacrylate as linker. The latter was reacted with succinic anhydride affording the carboxylic end useful for the immobilization of the antibiofilm molecules. The modified surface was characterized by scanning electron microscope, X-ray photoelectron spectroscopy, attenuated total reflectance Fourier transform infrared and fluorescence analyses. The antibiofilm activity of the modified materials were tested against Escherichia coli biofilm grown in the Center of Disease Control biofilm reactor. The results revealed that the grafted cinnamic and salicylic acid derivatives reduced biofilm biomass, in comparison with the control, by 73.7 ± 10.7% and 63.4 ± 7.1%, respectively.File | Dimensione | Formato | |
---|---|---|---|
s1-ln27055482153416615-1939656818Hwf-1723977146IdV78657633827055482PDF_HI0001(1).pdf
accesso aperto
Tipologia:
Pre-print (manoscritto inviato all'editore)
Dimensione
2.88 MB
Formato
Adobe PDF
|
2.88 MB | Adobe PDF | Visualizza/Apri |
Dell'orto_et_al-2017-Journal_of_Biomedical_Materials_Research_Part_A.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
762.94 kB
Formato
Adobe PDF
|
762.94 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.