Context: Histone modifications regulate gene expression; dysregulation has been linked with cardiovascular diseases. Associations between histone modification levels and blood pressure in humans are unclear. Objective: We examine the relationship between global histone concentrations and various markers of blood pressure. Materials and methods: Using the Beijing Truck Driver Air Pollution Study, we investigated global peripheral white blood cell histone modifications (H3K9ac, H3K9me3, H3K27me3, and H3K36me3) associations with pre- and post-work measurements of systolic (SBP) and diastolic (DBP) blood pressure, mean arterial pressure (MAP), and pulse pressure (PP) using multivariable mixed-effect models. Results: H3K9ac was negatively associated with pre-work SBP and MAP; H3K9me3 was negatively associated with pre-work SBP, DBP, and MAP; and H3K27me3 was negatively associated with pre-work SBP. Among office workers, H3K9me3 was negatively associated with pre-work SBP, DBP, and MAP. Among truck drivers, H3K9ac and H3K27me were negatively associated with pre-work SBP, and H3K27me3 was positively associated with post-work PP. Discussion and conclusion: Epigenome-wide H3K9ac, H3K9me3, and H3K27me3 were negatively associated with multiple pre-work blood pressure measures. These associations substantially changed during the day, suggesting an influence of daily activities. Blood-based histone modification biomarkers are potential candidates for studies requiring estimations of morning/pre-work blood pressure.
Histone 3 modifications and blood pressure in the Beijing Truck Driver Air Pollution Study / J.K. Kresovich, Z. Zhang, F. Fang, Y. Zheng, M. Sanchez-Guerra, B.T. Joyce, J. Zhong, Y. Chervona, S. Wang, D. Chang, J.P. Mccracken, A. Diaz, M. Bonzini, M. Carugno, P. Koutrakis, C. Kang, S. Bian, T. Gao, H. Byun, J. Schwartz, A.A. Baccarelli, L. Hou. - In: BIOMARKERS. - ISSN 1354-750X. - 22:6(2017), pp. 584-593.
|Titolo:||Histone 3 modifications and blood pressure in the Beijing Truck Driver Air Pollution Study|
|Parole Chiave:||Epigenetics; histone modifications; blood pressure; H3K9ac; H3K9me3; H3K27me3; H3K36me3|
|Settore Scientifico Disciplinare:||Settore MED/44 - Medicina del Lavoro|
|Data di pubblicazione:||2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1080/1354750X.2017.1347961|
|Appare nelle tipologie:||01 - Articolo su periodico|