Context: Histone modifications regulate gene expression; dysregulation has been linked with cardiovascular diseases. Associations between histone modification levels and blood pressure in humans are unclear. Objective: We examine the relationship between global histone concentrations and various markers of blood pressure. Materials and methods: Using the Beijing Truck Driver Air Pollution Study, we investigated global peripheral white blood cell histone modifications (H3K9ac, H3K9me3, H3K27me3, and H3K36me3) associations with pre- and post-work measurements of systolic (SBP) and diastolic (DBP) blood pressure, mean arterial pressure (MAP), and pulse pressure (PP) using multivariable mixed-effect models. Results: H3K9ac was negatively associated with pre-work SBP and MAP; H3K9me3 was negatively associated with pre-work SBP, DBP, and MAP; and H3K27me3 was negatively associated with pre-work SBP. Among office workers, H3K9me3 was negatively associated with pre-work SBP, DBP, and MAP. Among truck drivers, H3K9ac and H3K27me were negatively associated with pre-work SBP, and H3K27me3 was positively associated with post-work PP. Discussion and conclusion: Epigenome-wide H3K9ac, H3K9me3, and H3K27me3 were negatively associated with multiple pre-work blood pressure measures. These associations substantially changed during the day, suggesting an influence of daily activities. Blood-based histone modification biomarkers are potential candidates for studies requiring estimations of morning/pre-work blood pressure.
Histone 3 modifications and blood pressure in the Beijing Truck Driver Air Pollution Study / J.K. Kresovich, Z. Zhang, F. Fang, Y. Zheng, M. Sanchez Guerra, B.T. Joyce, J. Zhong, Y. Chervona, S. Wang, D. Chang, J.P. Mccracken, A. Diaz, M. Bonzini, M. Carugno, P. Koutrakis, C. Kang, S. Bian, T. Gao, H. Byun, J. Schwartz, A.A. Baccarelli, L. Hou. - In: BIOMARKERS. - ISSN 1354-750X. - 22:6(2017), pp. 584-593. [10.1080/1354750X.2017.1347961]
Histone 3 modifications and blood pressure in the Beijing Truck Driver Air Pollution Study
M. Bonzini;M. Carugno;
2017
Abstract
Context: Histone modifications regulate gene expression; dysregulation has been linked with cardiovascular diseases. Associations between histone modification levels and blood pressure in humans are unclear. Objective: We examine the relationship between global histone concentrations and various markers of blood pressure. Materials and methods: Using the Beijing Truck Driver Air Pollution Study, we investigated global peripheral white blood cell histone modifications (H3K9ac, H3K9me3, H3K27me3, and H3K36me3) associations with pre- and post-work measurements of systolic (SBP) and diastolic (DBP) blood pressure, mean arterial pressure (MAP), and pulse pressure (PP) using multivariable mixed-effect models. Results: H3K9ac was negatively associated with pre-work SBP and MAP; H3K9me3 was negatively associated with pre-work SBP, DBP, and MAP; and H3K27me3 was negatively associated with pre-work SBP. Among office workers, H3K9me3 was negatively associated with pre-work SBP, DBP, and MAP. Among truck drivers, H3K9ac and H3K27me were negatively associated with pre-work SBP, and H3K27me3 was positively associated with post-work PP. Discussion and conclusion: Epigenome-wide H3K9ac, H3K9me3, and H3K27me3 were negatively associated with multiple pre-work blood pressure measures. These associations substantially changed during the day, suggesting an influence of daily activities. Blood-based histone modification biomarkers are potential candidates for studies requiring estimations of morning/pre-work blood pressure.File | Dimensione | Formato | |
---|---|---|---|
2017e_Kresovich_Biomarkers.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
843.21 kB
Formato
Adobe PDF
|
843.21 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
1354750X.2017.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
1.18 MB
Formato
Adobe PDF
|
1.18 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.