ESCRT (Endosomal Sorting Complex Required for Transport) proteins have been shown to control an increasing number of membrane-associated processes. Some of these, and prominently regulation of receptor trafficking, profoundly shape signal transduction. Evidence in fungi, plants and multiple animal models support the emerging concept that ESCRTs are main actors in coordination of signaling with the changes in cells and tissues occurring during development and homeostasis. Consistent with their pleiotropic function, ESCRTs are regulated in multiple ways to tailor signaling to developmental and homeostatic needs. ESCRT activity is crucial to correct execution of developmental programs, especially at key transitions, allowing eukaryotes to thrive and preventing appearance of congenital defects.

ESCRT genes and regulation of developmental signaling / D. Horner, M..E. Pasini, M. Beltrame, V. Mastrodonato, E. Morelli, T. Vaccari. - In: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. - ISSN 1084-9521. - (2018 Aug 25). [Epub ahead of print] [10.1016/j.semcdb.2017.08.038]

ESCRT genes and regulation of developmental signaling

D. Horner;M..E. Pasini;M. Beltrame;V. Mastrodonato;E. Morelli;T. Vaccari
2018

Abstract

ESCRT (Endosomal Sorting Complex Required for Transport) proteins have been shown to control an increasing number of membrane-associated processes. Some of these, and prominently regulation of receptor trafficking, profoundly shape signal transduction. Evidence in fungi, plants and multiple animal models support the emerging concept that ESCRTs are main actors in coordination of signaling with the changes in cells and tissues occurring during development and homeostasis. Consistent with their pleiotropic function, ESCRTs are regulated in multiple ways to tailor signaling to developmental and homeostatic needs. ESCRT activity is crucial to correct execution of developmental programs, especially at key transitions, allowing eukaryotes to thrive and preventing appearance of congenital defects.
Development; ESCRT; Endocytosis; Endosome; Human disease; Notch; Signaling; Vps genes
Settore BIO/13 - Biologia Applicata
25-ago-2018
2017
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/522365
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