Alterations in signaling pathways that regulate resolution of inflammation (resolving pathways) contribute to pathogenesis of ulcerative colitis (UC). The resolution process is regulated by lipid mediators, such as those derived from the ω-3 docosahexaenoic acid (DHA), whose esterified form is transported by the major facilitator superfamily domain containing 2A (MFSD2A) through the endothelium of brain, retina, and placenta. We investigated if and how MFSD2A regulates lipid metabolism of gut endothelial cells to promote resolution of intestinal inflammation.

MFSD2A Promotes Endothelial Generation of Inflammation-resolving Lipid Mediators and Reduces Colitis in Mice / F. Ungaro, C. Tacconi, L. Massimino, P. Corsetto, C. Correale, P. Fonteyne, A. Piontini, V. Garzarelli, F. Calcaterra, S. Della Bella, A. Spinelli, M. Carvello, A. Rizzo, S. Vetrano, L. Petti, G. Fiorino, F. Furfaro, D. Mavilio, K. Maddipati, A. Malesci, L. Peyrin-Biroulet, S. D’Alessio, S. Danese. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - 153:5(2017 Nov), pp. 1363-1377.e6. [10.1053/j.gastro.2017.07.048]

MFSD2A Promotes Endothelial Generation of Inflammation-resolving Lipid Mediators and Reduces Colitis in Mice

F. Ungaro;C. Tacconi;P. Corsetto;C. Correale;A. Piontini;F. Calcaterra;S. Della Bella;A. Spinelli;A. Rizzo;L. Petti;F. Furfaro;D. Mavilio;A. Malesci;S. D’Alessio;
2017

Abstract

Alterations in signaling pathways that regulate resolution of inflammation (resolving pathways) contribute to pathogenesis of ulcerative colitis (UC). The resolution process is regulated by lipid mediators, such as those derived from the ω-3 docosahexaenoic acid (DHA), whose esterified form is transported by the major facilitator superfamily domain containing 2A (MFSD2A) through the endothelium of brain, retina, and placenta. We investigated if and how MFSD2A regulates lipid metabolism of gut endothelial cells to promote resolution of intestinal inflammation.
IBD; angiogenesis; gut vasculature; inflammatory bowel disease
Settore MED/09 - Medicina Interna
Settore BIO/10 - Biochimica
Settore MED/12 - Gastroenterologia
Settore MED/16 - Reumatologia
Settore MED/46 - Scienze Tecniche di Medicina di Laboratorio
nov-2017
4-ago-2017
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/522121
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