The enzymes adenylate deaminase (AMPDA) and adenosine deaminase (ADA) are able to catalyze the stereoselective hydrolytic deamination of (5'R,S)-methyl-2',3'-isopropylidene adenosine, but the 5'-butyl analog is a substrate only for AMPDA, which stereospecifically converts the (5'S)-isomer to the corresponding inosine derivative.

Stereoselective adenylate deaminase (5 '-adenylic acid deaminase, AMPDA)-catalyzed deamination of 5 '-alkyl substituted adenosines : A comparison with the action of adenosine deaminase (ADA) / P.Ciuffreda, A. Loseto, E. Santaniello. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 15:2(2004), pp. 203-206. [10.1016/j.tetasy.2003.11.007]

Stereoselective adenylate deaminase (5 '-adenylic acid deaminase, AMPDA)-catalyzed deamination of 5 '-alkyl substituted adenosines : A comparison with the action of adenosine deaminase (ADA)

P.Ciuffreda
Primo
;
E. Santaniello
Ultimo
2004

Abstract

The enzymes adenylate deaminase (AMPDA) and adenosine deaminase (ADA) are able to catalyze the stereoselective hydrolytic deamination of (5'R,S)-methyl-2',3'-isopropylidene adenosine, but the 5'-butyl analog is a substrate only for AMPDA, which stereospecifically converts the (5'S)-isomer to the corresponding inosine derivative.
INOSINE DERIVATIVES; ANALOGS
Settore BIO/10 - Biochimica
2004
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/5221
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