Post-resectional bronchopleural fistula is a pathological connection between the airway (bronchus) and the pleural space that may develop after lung resection; it may be caused by incomplete bronchial closure, impediment of bronchial stump wound healing, or stump destruction by residual neoplastic tissue. The clinical effect of impaired bronchial stump healing after anatomic lung resection may culminate in a life-threatening septic and ventilatory catastrophe. Stem cells can be used to repair defects in the airway wall, resulting from tumors, trauma, and diseases associated with epithelial damage; two groups of stem cells can be used for this purpose: endogenous progenitor cells present in the respiratory tract or exogenous stem cells derived from other tissues in the body; in this second group of stem cells there are embryonic stem cells, induced pluripotent stem cells, amniotic fluid stem cells, and fat-derived or bone marrow-derived mesenchymal stem cells (MSCs). Experimental and clinical evidence exists regarding MSC efficacy in airway defects restoration; although clinical MSC use—in the daily practice—is not yet reached for airway diseases, we can argue that MSC do not represent any more merely an experimental approach to airway tissue defects restoration but they can considered as a “salvage” therapeutic tool in very selected patients and diseases.

Mesenchymal Stem Cell Therapy for Airway Restoration Following Surgery / F. Petrella, S. Rizzo, F. Acocella, S. Brizzola, L. Spaggiari (STEM CELLS IN CLINICAL APPLICATIONS). - In: Liver, Lung and Heart Regeneration / [a cura di] P. Van Pham. - [s.l] : Springer International Publishing, 2017. - ISBN 9783319466927. - pp. 69-75 [10.1007/978-3-319-46693-4_5]

Mesenchymal Stem Cell Therapy for Airway Restoration Following Surgery

F. Petrella
Primo
;
F. Acocella;S. Brizzola
Penultimo
;
L. Spaggiari
Ultimo
2017

Abstract

Post-resectional bronchopleural fistula is a pathological connection between the airway (bronchus) and the pleural space that may develop after lung resection; it may be caused by incomplete bronchial closure, impediment of bronchial stump wound healing, or stump destruction by residual neoplastic tissue. The clinical effect of impaired bronchial stump healing after anatomic lung resection may culminate in a life-threatening septic and ventilatory catastrophe. Stem cells can be used to repair defects in the airway wall, resulting from tumors, trauma, and diseases associated with epithelial damage; two groups of stem cells can be used for this purpose: endogenous progenitor cells present in the respiratory tract or exogenous stem cells derived from other tissues in the body; in this second group of stem cells there are embryonic stem cells, induced pluripotent stem cells, amniotic fluid stem cells, and fat-derived or bone marrow-derived mesenchymal stem cells (MSCs). Experimental and clinical evidence exists regarding MSC efficacy in airway defects restoration; although clinical MSC use—in the daily practice—is not yet reached for airway diseases, we can argue that MSC do not represent any more merely an experimental approach to airway tissue defects restoration but they can considered as a “salvage” therapeutic tool in very selected patients and diseases.
Mesenchymal stem/stromal cells; Bronchoplerual fistula; Lung resection
Settore MED/21 - Chirurgia Toracica
Settore VET/09 - Clinica Chirurgica Veterinaria
Book Part (author)
File in questo prodotto:
File Dimensione Formato  
10.1007%2F978-3-319-46693-4_5.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 226.45 kB
Formato Adobe PDF
226.45 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/521156
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 0
social impact