Abstract: Objective: To describe a case of a 65-year-old woman with persistent olfactory hallucination and delusional self-reference, successfully treated by aripiprazole augmentation of antidepressant therapy. Background: Olfactory reference syndrome is a nosologic entity, which has been assimilated to various Diagnostic and Statistical Manual of Mental Disorder-IV-text revision codified diseases and several pharmacologic treatments have been proposed without a constant clinical response. Method: Psychiatric, neurologic, neuropsychologic, imaging, and electroencephalogram data are reported. Results: The patient showed a significant improvement with aripiprazole. Conclusions: We propose a pathophysiologic model of olfactory reference syndrome to explain the good response of our patient to aripiprazole. We hypothesize a disruption in the top-down regulation of the orbitofrontal cortex on the primary olfactory cortex and the olfactory bulb at the basis of the illness. Aripiprazole acting as a partial agonist of dopamine D2 receptors in the olfactory bulb compensates for the lack of modulation in this site, restoring the correct processing of olfactory information.
An olfactory reference syndrome successfully treated by aripiprazole augmentation of antidepressant therapy / R. Muffatti, S. Scarone, O. Gambini. - In: COGNITIVE AND BEHAVIORAL NEUROLOGY. - ISSN 1543-3633. - 21:4(2008), pp. 258-260.
An olfactory reference syndrome successfully treated by aripiprazole augmentation of antidepressant therapy
R. MuffattiPrimo
;S. ScaroneSecondo
;O. GambiniUltimo
2008
Abstract
Abstract: Objective: To describe a case of a 65-year-old woman with persistent olfactory hallucination and delusional self-reference, successfully treated by aripiprazole augmentation of antidepressant therapy. Background: Olfactory reference syndrome is a nosologic entity, which has been assimilated to various Diagnostic and Statistical Manual of Mental Disorder-IV-text revision codified diseases and several pharmacologic treatments have been proposed without a constant clinical response. Method: Psychiatric, neurologic, neuropsychologic, imaging, and electroencephalogram data are reported. Results: The patient showed a significant improvement with aripiprazole. Conclusions: We propose a pathophysiologic model of olfactory reference syndrome to explain the good response of our patient to aripiprazole. We hypothesize a disruption in the top-down regulation of the orbitofrontal cortex on the primary olfactory cortex and the olfactory bulb at the basis of the illness. Aripiprazole acting as a partial agonist of dopamine D2 receptors in the olfactory bulb compensates for the lack of modulation in this site, restoring the correct processing of olfactory information.Pubblicazioni consigliate
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