Objective To analyse the association between oral contraceptive use and the risk of uterine fibroids. Design We considered data collected in a case-control study on risk factors for uterine fibroids. Participants We studied 843 women with uterine fibroids, whose clinical diagnosis dated back no more than two years. Controls were 1557 non-hysterectomised patients younger than 55 years admitted for acute, non-gynecological, non-hormonal, non-neoplastic conditions. Results A total of 254 cases (30.1%) and 360 controls (23.1%) reported ever using oral contraceptives: the odds ratio (OR) for ever vs never users was 1.1 (95% CI 0.8-1.3). The risk in current users was below unity when compared with never users (OR 0.3, 95% CI 0.2-0.6), while ex-users had a risk of fibroids comparable with never users (OR 1.1, 95% CI 0.9-1.4). The risk of uterine fibroids decreased with duration of oral contraceptive use: compared with never users, the estimated OR was 0.8 (95% CI 0.5-1.2) in ever users for four to six years and 0.5 (95% CI 0.3-0.9) for seven years or more (chi(2) trend = 4.6, P = 0.03). Conclusions Although the role of selection bias should be carefully evaluated, the present data suggest that uterine fibroids should not be considered a contra-indication for oral contraceptive use.
Use of oral contraceptives and uterine fibroids: results from a case-control study / F. Chiaffarino, F. Parazzini, C. La Vecchia, S. Marsico, M. Surace, E. Ricci. - In: BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY. - ISSN 0306-5456. - 106:8(1999 Aug), pp. 857-860. [10.1111/j.1471-0528.1999.tb08409.x]
Use of oral contraceptives and uterine fibroids: results from a case-control study
F. Parazzini;C. La Vecchia;
1999
Abstract
Objective To analyse the association between oral contraceptive use and the risk of uterine fibroids. Design We considered data collected in a case-control study on risk factors for uterine fibroids. Participants We studied 843 women with uterine fibroids, whose clinical diagnosis dated back no more than two years. Controls were 1557 non-hysterectomised patients younger than 55 years admitted for acute, non-gynecological, non-hormonal, non-neoplastic conditions. Results A total of 254 cases (30.1%) and 360 controls (23.1%) reported ever using oral contraceptives: the odds ratio (OR) for ever vs never users was 1.1 (95% CI 0.8-1.3). The risk in current users was below unity when compared with never users (OR 0.3, 95% CI 0.2-0.6), while ex-users had a risk of fibroids comparable with never users (OR 1.1, 95% CI 0.9-1.4). The risk of uterine fibroids decreased with duration of oral contraceptive use: compared with never users, the estimated OR was 0.8 (95% CI 0.5-1.2) in ever users for four to six years and 0.5 (95% CI 0.3-0.9) for seven years or more (chi(2) trend = 4.6, P = 0.03). Conclusions Although the role of selection bias should be carefully evaluated, the present data suggest that uterine fibroids should not be considered a contra-indication for oral contraceptive use.Pubblicazioni consigliate
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