Cardiovascular (CV) comorbidities are a frequent extra-articular manifestation of rheumatoid arthritis (RA). Cardiovascular disease (CVD) with accelerated atherosclerosis is a major cause of morbidity and mortality in patients with RA. Subclinical CVD may be present since the early phase of RA. Not only traditional but also non-traditional CV risk factors are involved in the pathogenesis of RA-related CVD. Due to the lack of specifically designed randomized clinical trials, it is still unclear which tools to use to perform CV risk assessment, how to interpret the results and which interventions are appropriate in RA patients both to prevent and to manage CVD. Based on the available evidence, we propose a practical approach.

Practical Management of Cardiovascular Comorbidities in Rheumatoid Arthritis / R. Gualtierotti, N. Ughi, G. Marfia, F. Ingegnoli. - In: RHEUMATOLOGY AND THERAPY. - ISSN 2198-6584. - (2017 Jul 27). [Epub ahead of print] [10.1007/s40744-017-0068-0]

Practical Management of Cardiovascular Comorbidities in Rheumatoid Arthritis

R. Gualtierotti;UGHI, NICOLA;G. Marfia;F. Ingegnoli
2017-07-27

Abstract

Cardiovascular (CV) comorbidities are a frequent extra-articular manifestation of rheumatoid arthritis (RA). Cardiovascular disease (CVD) with accelerated atherosclerosis is a major cause of morbidity and mortality in patients with RA. Subclinical CVD may be present since the early phase of RA. Not only traditional but also non-traditional CV risk factors are involved in the pathogenesis of RA-related CVD. Due to the lack of specifically designed randomized clinical trials, it is still unclear which tools to use to perform CV risk assessment, how to interpret the results and which interventions are appropriate in RA patients both to prevent and to manage CVD. Based on the available evidence, we propose a practical approach.
accelerated atherosclerosis; biological drugs; cardiovascular comorbidities; cardiovascular disease; disease-modifying anti-rheumatic drugs; inflammation; rheumatoid arthritis
Settore MED/16 - Reumatologia
Settore MED/09 - Medicina Interna
27-lug-2017
Article (author)
File in questo prodotto:
File Dimensione Formato  
Practical management CV comorbidities RA.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 784.91 kB
Formato Adobe PDF
784.91 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/519636
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 10
social impact