Platelets play a central role in physiological hemostasis and also in pathological thrombosis. It is well established that congenital or acquired abnormalities of platelet function are associated with a heightened risk of bleeding of variable severity and excessive hemorrhage after surgery or trauma. Several kinds of different platelet function tests have been developed over the years to identify or diagnose platelet function disorders. The use of these tests for the assessment of thrombotic risk or for monitoring the effects of drugs inhibiting platelet function is not well established. Light transmission aggregometry (LTA) is the gold standard for the study of patients with defects of platelet function. Its results are affected by several pre-analytical and analytical variables. The Subcommittee on Platelet Physiology of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis published official guidelines for the standardization of the variables affecting LTA, which should be followed to harmonize the procedures across different laboratories worldwide. The lumi-aggregometer, a modification of LTA that measures platelet secretion in parallel with aggregation, is preferable to LTA for diagnosing inherited defects of platelet function, because it is more sensitive to the most common disorders, which are characterized by abnormalities of platelet secretion. LTA (or lumi-aggregometry) is useful as a first screening test of patients with the clinical suspicion of defects of platelet function, because it helps to provide an interim diagnostic hypothesis, which can then be confirmed or discounted using appropriate and specific tests.
Current and emerging approaches for evaluating platelet disorders / G. Podda, E.A. Femia, M. Cattaneo. - In: INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY. - ISSN 1751-5521. - 38:Suppl 1(2016 May), pp. 50-58. ((Intervento presentato al 29. convegno International Symposium on Technical Innovations in Laboratory Hematology : May, 12-14 tenutosi a Milano nel 2016.
|Titolo:||Current and emerging approaches for evaluating platelet disorders|
CATTANEO, MARCO NATALE (Ultimo)
|Parole Chiave:||platelet function disorder; light transmission aggregometry; lumi-aggregometry; platelet aggregation; platelet secretion; blood platelet disorders; blood platelets; humans; platelet aggregation; platelet function tests; practice guidelines as topic|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||mag-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/ijlh.12539|
|Appare nelle tipologie:||01 - Articolo su periodico|
File in questo prodotto:
|Podda_et_al-2016-International_Journal_of_Laboratory_Hematology Plt disorders.pdf||Publisher's version/PDF||Administrator Richiedi una copia|