The standard of practice in breast cancer surgery is that all patients with a positive sentinel node mandate an axillary lymph node dissection (ALND). Recently, this dogma has been challenged by a trial from ACOSOG (American College Of Surgeons Oncology Group) (Trial Z0011) which demonstrated that patients (without clinically/radiologically apparent axillary metastases) undergoing breast conserving surgery (i.e lumpectomy followed by whole breast radiotherapy) with positive sentinel nodes failed to derive any significant benefit by having an axillary lymph node dissection (ALND) . The logical progression from this study is to question the validity of performing routine axillary lymph node dissections on all patients with positive sentinel lymph nodes (SLN). In addition to the Z0011 trial, there is emerging data that additional patients exist who fail to derive any benefit from axillary surgery. The aim of this article is to discuss the potential subpopulations of patients that may avoid unnecessary ALND in the modern era of breast cancer management.
The evolving role of axillary lymph node dissection in the modern era of breast cancer management / J.M. Barry, W.P. Weber, V. Sacchini. - In: SURGICAL ONCOLOGY. - ISSN 0960-7404. - 21:2(2012), pp. 143-145.
|Titolo:||The evolving role of axillary lymph node dissection in the modern era of breast cancer management|
SACCHINI, VIRGILIO (Corresponding)
|Parole Chiave:||Axillary lymph node dissection; Positive sentinel lymph node management; Z0011 trial; Axilla; Breast Neoplasms; Female; Humans; Lymph Node Excision; Lymphatic Metastasis; Neoplasm Recurrence, Local; Sentinel Lymph Node Biopsy; Survival Analysis; Treatment Outcome; Oncology; Surgery|
|Settore Scientifico Disciplinare:||Settore MED/18 - Chirurgia Generale|
|Data di pubblicazione:||2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.suronc.2011.02.004|
|Appare nelle tipologie:||01 - Articolo su periodico|