The activity of telithromycin and comparator antibacterials was examined in isolates of Streptococcus pneumoniae and Haemophilus influenzae isolated from patients with community-acquired pneumonia (CAP), acute exacerbations of chronic bronchitis (AECB), or sinusitis during year 5 (2003-2004) of the Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin global resistance surveillance study. Among S. pneumoniae, penicillin nonsusceptibility and erythromycin resistance were 35.7% and 36.0%, respectively. β-Lactamase was produced by 12.3% of H. influenzae isolates. β-Lactamase-negative ampicillin-resistant strains, mainly from Japan, comprised 5.2% of global H. influenzae isolates. Telithromycin and levofloxacin were the most active agents tested against S. pneumoniae and H. influenzae (>99% of isolates susceptible) isolated from patients with CAP, AECB, or bacterial sinusitis. Amoxicillin-clavulanate, levofloxacin, and telithromycin were the most active agents against multidrug-resistant S. pneumoniae.
|Titolo:||Antibacterial activity of telithromycin and comparators against pathogens isolated from patients with community-acquired respiratory tract infections : the Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin study year 5 (2003-2004)|
BLASI, FRANCESCO BRUNO ARTURO (Primo)
|Parole Chiave:||Antibacterial surveillance; Community-acquired respiratory tract infections; Haemophilus influenzae; Streptococcus pneumoniae; Telithromycin|
|Settore Scientifico Disciplinare:||Settore MED/10 - Malattie dell'Apparato Respiratorio|
|Data di pubblicazione:||2009|
|Digital Object Identifier (DOI):||10.1016/j.diagmicrobio.2008.11.012|
|Appare nelle tipologie:||01 - Articolo su periodico|