Background. Hepatitis B virus infection and chronic kidney disease are prevalent and remain a major public health problem worldwide. It remains unclear how infection with hepatitis B virus impacts on the development and progression of chronic kidney disease. Aim. To evaluate the effect of infection with HBV on the risk of chronic kidney disease in the general population. Material and methods. We conducted a systematic review of the published medical literature to determine if hepatitis B infection is associated with increased likelihood of chronic kidney disease. We used the random effects model of DerSimonian and Laird to generate a summary estimate of the relative risk for chronic kidney disease (defined by reduced glomerular filtration rate and/or detectable proteinuria) with hepatitis B virus across the published studies. Meta-regression and stratified analysis were also conducted. Results. We identified 16 studies (n = 394,664 patients) and separate meta-analyses were performed according to the outcome. The subset of longitudinal studies addressing ESRD (n = 2; n = 91,656) gave a pooled aHR 3.87 (95% CI, 1.48; 6.25, P < 0.0001) among HBV-infected patients and no heterogeneity was recorded. In meta-regression, we noted the impact of male (P = 0.006) and duration of follow- up (P = 0.007) upon the adjusted hazard ratio of incidence of chronic kidney disease (including end-stage renal disease). No relationship occurred between HBV positive status and prevalent chronic disease (n = 7, n = 109,889 unique patients); adjusted odds ratio, were 1.07 (95% CI, 0.89; 1.25) and 0.93 (95% CI, 0.76; 1.10), respectively. Conclusions. HBV infection is possibly associated with a risk of developing reduced glomerular filtration rate in the general population; no link between HBV sero-positive status and frequency of chronic kidney disease or proteinuria was noted in cross-sectional surveys.
Association between hepatitis B virus and chronic kidney disease : a systematic review and meta-analysis / F. Fabrizi, F.M. Donato, P. Messa. - In: ANNALS OF HEPATOLOGY. - ISSN 1665-2681. - 16:1(2017 Feb), pp. 21-47.
|Titolo:||Association between hepatitis B virus and chronic kidney disease : a systematic review and meta-analysis|
MESSA, PIERGIORGIO (Ultimo)
|Parole Chiave:||chronic kidney disease; glomerular filtration rate; hepatitis B virus; meta-analysis; proteinuria; adult; aged; chi-square distribution; female; glomerular filtration rate; hepatitis B; humans; kidney; kidney failure, chronic; male; middle aged; observational studies as topic; odds ratio; prevalence; proteinuria; renal insufficiency, chronic; risk assessment; risk factors; time factors; hepatology|
|Settore Scientifico Disciplinare:||Settore MED/14 - Nefrologia|
|Data di pubblicazione:||feb-2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.5604/16652681.1226813|
|Appare nelle tipologie:||01 - Articolo su periodico|