An efficient multicomponent domino process that works under mild conditions was used for the synthesis of systematically modified neomycin-sugar conjugates. The final aminoglycoside derivatives were tested against methicillin-resistant Staphylococcus aureus, Klebsiella, and E. coli strains, and show activity comparable to the parent antibiotics. Such a strategy can impact multicomponent combinatorial syntheses of diverse biologically active conjugates.
Multicomponent Domino Synthesis and Antibacterial Activity of Neomycin-Sugar Conjugates / A. Sganappa, M.C. Bellucci, V. Nizet, Y. Tor, A. Volonterio. - In: SYNTHESIS. - ISSN 0039-7881. - 48:24(2016 Dec), pp. 4443-4450. [10.1055/s-0035-1562727]
Multicomponent Domino Synthesis and Antibacterial Activity of Neomycin-Sugar Conjugates
M.C. BellucciSecondo
;
2016
Abstract
An efficient multicomponent domino process that works under mild conditions was used for the synthesis of systematically modified neomycin-sugar conjugates. The final aminoglycoside derivatives were tested against methicillin-resistant Staphylococcus aureus, Klebsiella, and E. coli strains, and show activity comparable to the parent antibiotics. Such a strategy can impact multicomponent combinatorial syntheses of diverse biologically active conjugates.File | Dimensione | Formato | |
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