An efficient multicomponent domino process that works under mild conditions was used for the synthesis of systematically modified neomycin-sugar conjugates. The final aminoglycoside derivatives were tested against methicillin-resistant Staphylococcus aureus, Klebsiella, and E. coli strains, and show activity comparable to the parent antibiotics. Such a strategy can impact multicomponent combinatorial syntheses of diverse biologically active conjugates.

Multicomponent Domino Synthesis and Antibacterial Activity of Neomycin-Sugar Conjugates / A. Sganappa, M.C. Bellucci, V. Nizet, Y. Tor, A. Volonterio. - In: SYNTHESIS. - ISSN 0039-7881. - 48:24(2016 Dec), pp. 4443-4450. [10.1055/s-0035-1562727]

Multicomponent Domino Synthesis and Antibacterial Activity of Neomycin-Sugar Conjugates

M.C. Bellucci
Secondo
;
2016

Abstract

An efficient multicomponent domino process that works under mild conditions was used for the synthesis of systematically modified neomycin-sugar conjugates. The final aminoglycoside derivatives were tested against methicillin-resistant Staphylococcus aureus, Klebsiella, and E. coli strains, and show activity comparable to the parent antibiotics. Such a strategy can impact multicomponent combinatorial syntheses of diverse biologically active conjugates.
aminoglycosides; antibiotics; carbodiimides; domino reaction; multicomponent reaction; catalysis; organic chemistry
Settore CHIM/06 - Chimica Organica
dic-2016
16-ago-2016
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/515407
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