β-Adrenergic and GABA receptor binding were measured in brain areas of rats 3 to 24 months of age. While GABA receptor binding was not significantly different across age in any area, β-adrenergic receptor binding was significantly reduced in the cerebellum and brain stem, but not cerebral cortex, of 24-month-old animals. The loss in β-adrenergic receptor binding does not correlate in a temporal fashion with the reported decrease in norepinephrine-stimulated cyclic AMP accumulation in the cerebellum which occurs as early as 12 months of age. An age-related reduction in β-adrenergic binding was also noted in human cerebellar tissue obtained at autopsy, suggesting that the cerebellar dysfunction seen with aging may be related to a loss of cerebellar neurons which receive noradrenergic input.
|Titolo:||Effect of aging on neurotransmitter receptor binding in rat and human brain|
MAGGI, ADRIANA CATERINA (Primo)
|Parole Chiave:||Adult; Aged; Alprenolol; Animals; Brain; Cerebellum; Cyclic AMP; Humans; In Vitro Techniques; Infant; Infant, Newborn; Male; Middle Aged; Neurotransmitter Agents; Norepinephrine; Rats; Receptors, Adrenergic, beta; Receptors, Cell Surface; Species Specificity; gamma-Aminobutyric Acid; Aging|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1979|
|Digital Object Identifier (DOI):||10.1016/0024-3205(79)90333-3|
|Appare nelle tipologie:||01 - Articolo su periodico|