Our data indicate that estrogens and progesterone can regulate the number of GABA receptors (as detected by [3H]muscimol binding assay) in rat brain. Both hormones act in selected areas. The extent of the effect (up to 160% increase) and the number of areas responsive suggest that sex hormones may play a very important role in the regulation of the functions of GABAergic transmission in the central nervous system.
Progesterone and estrogens in rat brain: modulation of GABA (gamma-aminobutyric acid) receptor activity / A. Maggi, J. Perez. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 103:1-2(1984), pp. 165-168. [10.1016/0014-2999(84)90205-X]
Progesterone and estrogens in rat brain: modulation of GABA (gamma-aminobutyric acid) receptor activity
A. MaggiPrimo
;
1984
Abstract
Our data indicate that estrogens and progesterone can regulate the number of GABA receptors (as detected by [3H]muscimol binding assay) in rat brain. Both hormones act in selected areas. The extent of the effect (up to 160% increase) and the number of areas responsive suggest that sex hormones may play a very important role in the regulation of the functions of GABAergic transmission in the central nervous system.
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