Acute lung injury and acute respiratory distress syndrome are characterized by a non-cardiogenic pulmonary edema responsible for a significant impairment of gas exchange. The pulmonary dead space increase, which is due primarily to an alteration in pulmonary blood flow distribution, is largely responsible for carbon dioxide retention. Previous studies, computing the pulmonary dead space by measuring the expired carbon dioxide and the Enghoff equation, found that the dead space fraction was significantly higher in the non-survivors; it was even an independent risk of death. The computation of the dead space not by measuring the expired carbon dioxide but by applying a rearranged alveolar gas equation that takes into account only the weight, age, height, and temperature of the patient could lead to widespread clinical diffusion of this measurement at the bedside.
Estimation of dead space fraction can be simplified in the acute respiratory distress syndrome / D. Chiumello, E. Gallazzi. - In: CRITICAL CARE. - ISSN 1364-8535. - 14:5(2010), pp. 195.1-195.2.
|Titolo:||Estimation of dead space fraction can be simplified in the acute respiratory distress syndrome|
CHIUMELLO, DAVIDE ALBERTO (Corresponding)
GALLAZZI, ELISABETTA (Ultimo)
|Parole Chiave:||Animals; Humans; Pulmonary Alveoli; Pulmonary Gas Exchange; Respiratory Dead Space; Respiratory Distress Syndrome, Adult; Respiratory Function Tests; Critical Care and Intensive Care Medicine|
|Settore Scientifico Disciplinare:||Settore MED/41 - Anestesiologia|
|Data di pubblicazione:||2010|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1186/cc9237|
|Appare nelle tipologie:||01 - Articolo su periodico|