Recent work revealed the major role played by liver Estrogen Receptor α (ERα) in the regulation of metabolic and reproductive functions. By using mutant mice with liver-specific ablation of Erα, we here demonstrate that the hepatic ERα is essential for the modulation of the activity of Agouti Related Protein (AgRP) neurons in relation to the reproductive cycle and diet. Our results suggest that the alterations of hepatic lipid metabolism due to the lack of liver ERα activity are responsible for a neuroinflammatory status that induces refractoriness of AgRP neurons to reproductive and dietary stimuli. The study therefore points to the liver ERα as a necessary sensor for the coordination of systemic energy metabolism and reproductive functions.

Liver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice / V. Benedusi, S. Della Torre, N. Mitro, D. Caruso, A. Oberto, C.A. Tronel, C. Meda, A. Maggi. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 7:1(2017 Apr), pp. 1194.1-1194.13. [10.1038/s41598-017-01393-0]

Liver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice

BENEDUSI, VALERIA;S. Della Torre;N. Mitro;D. Caruso;TRONEL, CLAIRE AGNES;MEDA, CLARA;A. Maggi
2017-04

Abstract

Recent work revealed the major role played by liver Estrogen Receptor α (ERα) in the regulation of metabolic and reproductive functions. By using mutant mice with liver-specific ablation of Erα, we here demonstrate that the hepatic ERα is essential for the modulation of the activity of Agouti Related Protein (AgRP) neurons in relation to the reproductive cycle and diet. Our results suggest that the alterations of hepatic lipid metabolism due to the lack of liver ERα activity are responsible for a neuroinflammatory status that induces refractoriness of AgRP neurons to reproductive and dietary stimuli. The study therefore points to the liver ERα as a necessary sensor for the coordination of systemic energy metabolism and reproductive functions.
multidisciplinary
Settore BIO/14 - Farmacologia
Role of the Liver Estrogen Receptor in female Energy Metabolism, Reproduction and Aging: What About Your Liver Sexual Functions?
Imaging of Neuroinflammation in Neurodegenerative Diseases
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/513548
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