Mimics of oligosaccharides are under current investigation by a number of groups striving to produce tools for glycobiology and to design antagonists of medically relevant lectins. This chapter reviews trends that have developed over the past 5 years (2010-2014) in the field, focusing on three topics that we believe are providing the most interesting progress: (a) multivalent sugar-processing enzyme inhibitors; (b) synthesis of oligosaccharide and glycoconjugate mimics with unnatural glycosidic bonds/linkers and (c) use of second site interactions in monosaccharide-anchored lectin antagonists.
Design and synthesis of glycomimetics / S. Sattin, A. Bernardi (CARBOHYDRATE CHEMISTRY). - In: Carbohydrate Chemistry. 41 / [a cura di] A.P. Rauter, T.K. Lindhorst, Y. Queneau. - [s.l] : Royal Society of Chemistry, 2016. - ISBN 9781782621218. - pp. 1-25
Design and synthesis of glycomimetics
S. SattinPrimo
;A. BernardiUltimo
2016
Abstract
Mimics of oligosaccharides are under current investigation by a number of groups striving to produce tools for glycobiology and to design antagonists of medically relevant lectins. This chapter reviews trends that have developed over the past 5 years (2010-2014) in the field, focusing on three topics that we believe are providing the most interesting progress: (a) multivalent sugar-processing enzyme inhibitors; (b) synthesis of oligosaccharide and glycoconjugate mimics with unnatural glycosidic bonds/linkers and (c) use of second site interactions in monosaccharide-anchored lectin antagonists.File | Dimensione | Formato | |
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