Mimics of oligosaccharides are under current investigation by a number of groups striving to produce tools for glycobiology and to design antagonists of medically relevant lectins. This chapter reviews trends that have developed over the past 5 years (2010-2014) in the field, focusing on three topics that we believe are providing the most interesting progress: (a) multivalent sugar-processing enzyme inhibitors; (b) synthesis of oligosaccharide and glycoconjugate mimics with unnatural glycosidic bonds/linkers and (c) use of second site interactions in monosaccharide-anchored lectin antagonists.

Design and synthesis of glycomimetics / S. Sattin, A. Bernardi (CARBOHYDRATE CHEMISTRY). - In: Carbohydrate Chemistry. 41 / [a cura di] A.P. Rauter, T.K. Lindhorst, Y. Queneau. - [s.l] : Royal Society of Chemistry, 2016. - ISBN 9781782621218. - pp. 1-25

Design and synthesis of glycomimetics

S. Sattin;A. Bernardi
2016

Abstract

Mimics of oligosaccharides are under current investigation by a number of groups striving to produce tools for glycobiology and to design antagonists of medically relevant lectins. This chapter reviews trends that have developed over the past 5 years (2010-2014) in the field, focusing on three topics that we believe are providing the most interesting progress: (a) multivalent sugar-processing enzyme inhibitors; (b) synthesis of oligosaccharide and glycoconjugate mimics with unnatural glycosidic bonds/linkers and (c) use of second site interactions in monosaccharide-anchored lectin antagonists.
Mediated HIV-infection; traceless Staudinger ligation; ligands selectin antagonists; iminosugar click clusters; urinary-tract-infections; DC-sign; stereoselective-synthesis; FIMH antagonists; pseudomonas-aeruginosa; pharmacological chaperones
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/513466
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