Heparin-induced thrombocytopenia and thrombosis (HITT) represents a dramatic condition that is difficult to diagnose because of nuanced clinical presentation. Therefore, in every case of microvascular thrombosis during heparin-therapy prompt suspicion about HITT is necessary to avoid flap necrosis. We present a case of HITT which, as the 8 other articles reviewed, clearly shows that HITT is difficult to diagnose and complex to manage. Microvascular reconstruction is the first choice in head and neck reconstruction; unfortunately, dramatic outcomes in free flap surgery due to unpredictable thrombotic events are still reported in the English literature. More knowledge is required about HITT and reaching a consensus about thrombotic prevention in microsurgery could be helpful. Furthermore, a careful anamnesis can help minimise unexpected situations.

Free flap loss caused by heparin-induced thrombocytopenia and thrombosis (HITT) : a case report and literature review = Trombocitopenia eparino-indotta e trombosi (HITT): Una causa sottostimata di fallimento di lembi liberi : Case report e revisione della letteratura / E. Segna, A.R. Bolzoni, C. Baserga, A. Baj. - In: ACTA OTORHINOLARYNGOLOGICA ITALICA. - ISSN 0392-100X. - 36:6(2016), pp. 527-533. [10.14639/0392-100X-1188]

Free flap loss caused by heparin-induced thrombocytopenia and thrombosis (HITT) : a case report and literature review = Trombocitopenia eparino-indotta e trombosi (HITT): Una causa sottostimata di fallimento di lembi liberi : Case report e revisione della letteratura

A.R. Bolzoni;C. Baserga;A. Baj
Ultimo
2016

Abstract

Heparin-induced thrombocytopenia and thrombosis (HITT) represents a dramatic condition that is difficult to diagnose because of nuanced clinical presentation. Therefore, in every case of microvascular thrombosis during heparin-therapy prompt suspicion about HITT is necessary to avoid flap necrosis. We present a case of HITT which, as the 8 other articles reviewed, clearly shows that HITT is difficult to diagnose and complex to manage. Microvascular reconstruction is the first choice in head and neck reconstruction; unfortunately, dramatic outcomes in free flap surgery due to unpredictable thrombotic events are still reported in the English literature. More knowledge is required about HITT and reaching a consensus about thrombotic prevention in microsurgery could be helpful. Furthermore, a careful anamnesis can help minimise unexpected situations.
blood coagulation disorder; drug-related side effects and adverse reactions; microsurgical free flap; thrombosis; otorhinolaryngology2734 pathology and forensic medicine
Settore MED/29 - Chirurgia Maxillofacciale
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/510515
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