We investigated the effects of glucose and diverse breakfasts on glucose increment and ghrelin suppression and cognitive processing of sensory information assessed by frontal P300 evoked potentials. In a randomized crossover design, 12 healthy individuals (6M/6F; BMI 22.2 ± 0.4 kg/m2; 27 ± 1.3 years, mean ± SEM) underwent 50 g OGTT (A) and 3 breakfasts (B1: milk and cereals; B2: milk, apple, and chocolate cream-filled sponge cake; B3: milk, apple, bread, and hazelnut chocolate cream) to assess plasma glucose-, insulin-, and ghrelin excursions. An electroencephalography was performed before and 100 min after consumption of each load to measure the latency of frontal P300 evoked potentials as index of cognitive performance. Breakfasts B1 and B2 exhibited significantly lower glycemic and insulinemic responses as compared to A. Breakfast B3 exhibited significantly lower glycemic, but not insulinemic response, as compared to A. Final plasma ghrelin inhibition was more pronounced, albeit not significantly, in all breakfasts with respect to A. P300 latency tended to decrease following each of the three breakfasts, but B3 was the only breakfast capable to elicit a statistically significant reduction in P300 latency with respect to A (), suggesting ameliorated cognitive performance. Such amelioration was correlated with the 2-hour final inhibition of plasma ghrelin concentration (r = 0.61, p = 0.01).
Effect of Sugar versus Mixed Breakfast on Metabolic and Neurofunctional Responses in Healthy Individuals / R. Codella, S. Benedini, S. Paini, A. Caumo, M. Adamo, I. Terruzzi, A. Ferrulli, C. Macrì, L. Andreoni, M. Sterlicchio, L. Luzi. - In: JOURNAL OF DIABETES RESEARCH. - ISSN 2314-6745. - 2017(2017), pp. 9634585.1-9634585.10. ((Intervento presentato al 75. convegno American Diabetes Association (ADA) tenutosi a Boston nel 2015.
|Titolo:||Effect of Sugar versus Mixed Breakfast on Metabolic and Neurofunctional Responses in Healthy Individuals|
CODELLA, ROBERTO (Primo)
BENEDINI, STEFANO (Secondo)
LUZI, LIVIO (Ultimo)
|Parole Chiave:||ghrelin; breakfast meal; P300|
|Settore Scientifico Disciplinare:||Settore M-EDF/02 - Metodi e Didattiche delle Attivita' Sportive|
Settore MED/13 - Endocrinologia
Settore BIO/09 - Fisiologia
|Data di pubblicazione:||2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1155/2017/9634585|
|Appare nelle tipologie:||01 - Articolo su periodico|