Introduction Cancer heterogeneity and degree of intra-tumoral immune cells represent variables affecting overall survival (OS). The present study investigated the impact of natural killer (NK) and T cells infiltrating colorectal liver metastases (CLM) in patients undergoing hepatectomy after neoadjuvant chemotherapy. Methods The frequencies of intra-tumoral, marginal, and peritumoral CD3+ T and NKp46+ NK cells were determined for 121 patients. OS was assessed in relation to prognostic factors. Results At univariate analysis, several variables, including T and N of the primary tumor, metachronous CLM, radiological response, and higher density of intra-tumoral CD3+ T cell (>1%/mm(2)) and of NKp46+ NK cells (>1 cell/mm(2)), were associated with OS. Only increased frequencies of intra-tumoral CD3+ Tcells (p = 0.005) and NKp46+ NK cells (p = 0.004) correlated with OS at multivariate analysis. The logistic regression revealed that metachronous CLM (OR = 2.781; p = 0.002), the use of an epidermal growth factor receptor inhibitor (OR = 3.891; p = 0.001), and radiological response (OR = 3.219; p = 0.001) were associated with higher infiltration of these cells. Conclusions High frequencies of NK and T cells in response to chemotherapy predict OS in CLM patients. These findings provide important insights that can help physicians to choose the best treatment option and adopt more predictive follow-up strategies for patients with CLM.
Increased Infiltration of Natural Killer and T Cells in Colorectal Liver Metastases Improves Patient Overall Survival / M. Donadon, K. Hudspeth, M. Cimino, L. Di Tommaso, M. Preti, P. Tentorio, M. Roncalli, D. Mavilio, G. Torzilli. - In: JOURNAL OF GASTROINTESTINAL SURGERY. - ISSN 1091-255X. - 21:8(2017), pp. 1226-1236. ((Intervento presentato al convegno Meeting of the Society-for-Surgery-of-the-Alimentary-Tract (SSAT) tenutosi a San Diego nel 2016.
|Titolo:||Increased Infiltration of Natural Killer and T Cells in Colorectal Liver Metastases Improves Patient Overall Survival|
DONADON, MATTEO DAVIDE (Primo)
HUDSPETH, KELLY LORRAINE (Secondo)
MAVILIO, DOMENICO (Penultimo)
TORZILLI, GUIDO (Corresponding)
|Parole Chiave:||Colorectal liver metastases; Chemotherapy; Natural killer cells; Tcells; Immune response to colorectal liver metastases|
|Settore Scientifico Disciplinare:||Settore MED/46 - Scienze Tecniche di Medicina di Laboratorio|
Settore MED/04 - Patologia Generale
Settore MED/06 - Oncologia Medica
|Data di pubblicazione:||2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s11605-017-3446-6|
|Appare nelle tipologie:||01 - Articolo su periodico|