A direct and independent association between serum phosphate (P) levels and mortality has been reported. High circulating P concentrations, still within the normal range, was associated with unfavourable outcomes in normal subjects as well as in chronic kidney disease (CKD) patients. Experimental data support the notion that P overload may hamper survival expectancy, directly inducing vascular, skeletal, and renal ageing. The balance of P results from dietary intake, intestinal absorption, glomerular filtration, tubular resorption, and hormonal asset. However, the accurate estimation of P balance is hampered by several methodological weaknesses, becoming even critical when renal function declines. Increasing evidence in the physiology of P metabolism in humans counteracts with uncertainties on dietary P intake and P balance assessment from general population and CKD subjects.

Phosphate in chronic kidney disease progression / M. Cozzolino, D. Foque, P. Ciceri, A. Galassi. - In: CONTRIBUTIONS TO NEPHROLOGY. - ISSN 0302-5144. - 190(2017 May), pp. 71-82. [10.1159/000468915]

Phosphate in chronic kidney disease progression

M. Cozzolino
Primo
;
P. Ciceri
Penultimo
;
A. Galassi
Ultimo
2017

Abstract

A direct and independent association between serum phosphate (P) levels and mortality has been reported. High circulating P concentrations, still within the normal range, was associated with unfavourable outcomes in normal subjects as well as in chronic kidney disease (CKD) patients. Experimental data support the notion that P overload may hamper survival expectancy, directly inducing vascular, skeletal, and renal ageing. The balance of P results from dietary intake, intestinal absorption, glomerular filtration, tubular resorption, and hormonal asset. However, the accurate estimation of P balance is hampered by several methodological weaknesses, becoming even critical when renal function declines. Increasing evidence in the physiology of P metabolism in humans counteracts with uncertainties on dietary P intake and P balance assessment from general population and CKD subjects.
Settore MED/14 - Nefrologia
mag-2017
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/501895
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