We describe a 72-year-old woman with a 13-year history of a lichenoid dermatitis, who developed multiple, papular keratoacanthoma (KA)-like lesions and few crater-like nodules on the extremities over a period of 6 months before our observation. Her medical history also recorded multiple myeloma diagnosed a few years before. The long-standing dermatosis was diagnosed, clinically, as keratosis lichenoides chronica (KLC), although, histologically, a lichenoid tissue reaction pattern was not evident. On the other hand, histology from papular and nodular lesions of recent onset was consistent with a possible early phase of KA and spinocellular carcinoma, respectively. Oral acitretin induced regression of KA-like lesions and improvement of KLC but had no effects on crater-like nodules, which required surgical excision, KLC is a chronic disorder of keratinization characterized by lichenoid hyperkeratotic papules arranged in a linear pattern, erythematosquamous plaques and seborrhoea-like dermatitis. We emphasize in our case the association between KLC and multiple possible KAs, never previously reported, and speculate that these two rare conditions may represent here a 'continuum' from a pathogenetic point of view. (copyright) 2004 European Academy of Dermatology and Venereology.
Keratosis lichenoides chronica and eruptive keratoacanthoma-like lesions in a patient with multiple myeloma / A.V. Marzano, M. Bellinvia, R. Caputo, E. Alessi. - In: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. - ISSN 0926-9959. - 19:1(2005), pp. 129-133.
|Titolo:||Keratosis lichenoides chronica and eruptive keratoacanthoma-like lesions in a patient with multiple myeloma|
BELLINVIA, MONICA (Secondo)
CAPUTO, RUGGERO (Penultimo)
ALESSI, ELVIO GIUSEPPE ANGELO (Ultimo)
|Parole Chiave:||aged; anamnesis; article; case report; chronic disease; dermatitis; disease association; dyskeratosis; erythema; excision; female; histopathology; human cell; human tissue; human; hyperkeratosis; keratoacanthoma; keratosis; lichenoid eruption; multiple myeloma; papule; pathogenesis; priority journal; rash; seborrhea; skin carcinoma; skin defect; skin nodule; skin surgery; tissue reaction; etretin|
|Settore Scientifico Disciplinare:||Settore MED/35 - Malattie Cutanee e Veneree|
|Data di pubblicazione:||2005|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/j.1468-3083.2004.01112.x|
|Appare nelle tipologie:||01 - Articolo su periodico|