The research I present will focus on the design of knowledge intensive interactive systems able to facilitate an effective collection, organization, interaction, valorisation and experience of cultural heritage (CH). The effective presentation of cultural heritage information, typically complex and rich, requires sophisticated systems integrating techniques from different areas, mainly human computer interaction (HCI) and knowledge management. The key is the design of information architectures able to combine different fruition data patterns into specific interactive environments. Cultural heritage is a knowledge intensive domain that requires information interaction techniques in order to address the complexity of the information and knowledge base in each cultural aspect. This research proposes a conceptual framework for interaction methods in the context of knowledge-intensive interactive systems; the goal of such methods is to exploit mechanisms for integrating, enhancing and interacting with information in a form that responds to the fruition context of the final user.