OBJECTIVES: To test whether left ventricular (LV) dysfunction affecting type 1 diabetic-uremic patients was associated with abnormal heart high-energy phosphates (HEPs) and to ascertain whether these alterations were also present in recipients of kidney or kidney-pancreas transplantation. BACKGROUND: Heart failure is the major determinant of mortality in patients with diabetic uremia. Both uremia and diabetes induce alterations of cardiac HEPs metabolism. METHODS: Magnetic resonance imaging and phosphorous magnetic resonance spectroscopy of the LV were performed in the resting state by means of a 1.5-T clinical scanner. Eleven diabetic-uremic patients, 5 nondiabetic patients with uremia, 11 diabetic recipients of kidney transplantation, and 16 diabetic recipients of combined kidney-pancreas transplantation were studied in a cross-sectional fashion. Eleven nondiabetic recipients of kidney-only transplant and 13 healthy subjects served as control groups. RESULTS: Uremic patients had higher LV mass, diastolic dysfunction, and lower phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio in comparison with recipients of kidney-pancreas or nondiabetic recipients of kidney transplant. In diabetic recipients of kidney transplant the PCr/ATP ratio was higher than in uremic patients but was lower than in the controls. Recipients of combined kidney-pancreas transplant had a higher ratio than uremic patients but no difference was found in comparison with controls. CONCLUSIONS: Altered resting myocardial HEPs metabolism may contribute to LV dysfunction in diabetic-uremic patients. In diabetic recipients of kidney transplantation, a certain degree of LV metabolic and functional impairment was found. In combined kidney-pancreas recipients the resting LV metabolism and function were not different than in controls.
Cross-sectional assessment of the effect of kidney and kidney-pancreas transplantation on resting left ventricular energy metabolism in type 1 diabetic-uremic patients : a phosphorous-31 magnetic resonance spectroscopy study / G. Perseghin, P. Fiorina, F. De Cobelli, P. Scifo, A. Esposito, T. Canu, M. Danna, C. Gremizzi, A. Secchi, L. Luzi, A. Del Maschio. - In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. - ISSN 0735-1097. - 46:6(2005 Sep 20), pp. 1085-1092.
|Titolo:||Cross-sectional assessment of the effect of kidney and kidney-pancreas transplantation on resting left ventricular energy metabolism in type 1 diabetic-uremic patients : a phosphorous-31 magnetic resonance spectroscopy study|
PERSEGHIN, GIANLUCA (Primo)
FIORINA, PAOLO (Secondo)
LUZI, LIVIO (Penultimo)
|Parole Chiave:||Adenosine Triphosphate; Aged; Cross-Sectional Studies; Diabetes Complications; Diabetes Mellitus, Type 1; Female; Heart Ventricles; Humans; Male; Middle Aged; Phosphocreatine; Phosphorus Isotopes; Uremia; Ventricular Dysfunction, Left; Energy Metabolism; Kidney Transplantation; Magnetic Resonance Spectroscopy; Pancreas Transplantation; Nursing (all)2901 Nursing (miscellaneous)|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
Settore BIO/09 - Fisiologia
|Data di pubblicazione:||20-set-2005|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.jacc.2005.05.075|
|Appare nelle tipologie:||01 - Articolo su periodico|