Regulatory T cells (Tregs) actively regulate alloimmune responses and promote transplantation tolerance. Thymoglobulin, a rabbit polyclonal antithymocyte globulin (ATG), is a widely used induction therapy in clinical organ transplantation that depletes peripheral T cells. However, resistance to tolerance induction is seen with certain T-cell depleting strategies and is attributed to alterations in the balance of naive, memory and Tregs. The exact mechanism of action of ATG and its effects on the homeostasis and balance between Tregs and T-effector-memory cells (Tem) are unknown.
A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model / F. D'Addio, X. Yuan, A. Habicht, J. Williams, M. Ruzek, J. Iacomini, L.A. Turka, M.H. Sayegh, N. Najafian, M.J. Ansari. - In: TRANSPLANTATION. - ISSN 1534-6080. - 90:3(2010 Aug 15), pp. 260-269. [10.1097/TP.0b013e3181e64217]
A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model
F. D'AddioPrimo
;
2010
Abstract
Regulatory T cells (Tregs) actively regulate alloimmune responses and promote transplantation tolerance. Thymoglobulin, a rabbit polyclonal antithymocyte globulin (ATG), is a widely used induction therapy in clinical organ transplantation that depletes peripheral T cells. However, resistance to tolerance induction is seen with certain T-cell depleting strategies and is attributed to alterations in the balance of naive, memory and Tregs. The exact mechanism of action of ATG and its effects on the homeostasis and balance between Tregs and T-effector-memory cells (Tem) are unknown.File | Dimensione | Formato | |
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NovelClinicallyRelevant_2010.pdf
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