BACKGROUND AND OBJECTIVES:Textbooks and reviews do not mention the association of symptomatic primary Epstein-Barr virus infectious mononucleosis with acute kidney injury in subjects without immunodeficiency or autoimmunity. STUDY DESIGN: Stimulated by our experience with two cases, we performed a review of the literature. RESULTS: The literature documents 38 cases (26 male and 12 female individuals ranging in age from 0.3 to 51, median 18 years) of symptomatic primary Epstein-Barr virus infectious mononucleosis complicated by acute kidney injury: 27 acute interstitial nephritides, 1 jaundice-associated nephropathy, 7 myositides and 3 hemolytic uremic syndromes. Acute kidney injury requiring renal replacement therapy was observed in 18 (47%) cases. Acute kidney injury did not resolve in one patient with acute interstitial nephritis. Two patients died because of systemic complications. The remaining 35 cases fully recovered. CONCLUSIONS: In individuals with acute symptomatic Epstein-Barr virus infectious mononucleosis, a relevant kidney injury is rare but the outcome potentially fatal. It results from interstitial nephritis, myositis-associated acute kidney injury, hemolytic uremic syndrome or jaundice-associated nephropathy.
|Titolo:||Acute kidney injury in symptomatic primary Epstein-Barr virus infectious mononucleosis : systematic review|
MILANI, GREGORIO PAOLO (Ultimo)
|Parole Chiave:||Acute kidney injury; Epstein-Barr virus infections; Hemolytic-uremic syndrome; Interstitial; Myositis; Nephritis|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
|Data di pubblicazione:||giu-2017|
|Digital Object Identifier (DOI):||10.1016/j.jcv.2017.03.016|
|Appare nelle tipologie:||01 - Articolo su periodico|