OBJECTIVE -This retrospective study was designed to identify metabolic and immune predictors of early islet allograft failure. RESEARCH DESIGN AND METHODS -We measured several metabolic and immunological markers at the time of pretransplant and several time points posttransplantation in 17 patients with long-term functioning graft (long fx) and 20 patients with short-term functioning graft (short fx). RESULTS -The short fx group showed higher insulin resistance, altered proinsulin processing, lower soluble interleukin-2 receptor (sIL-2r) (marker of T-cell activation), and higher soluble FasL (marker of apoptosis) during the entire follow-up, particularly at time of failure. CONCLUSIONS -Patients who experienced an early failure of islet allograft showed specific metabolic and immunological signs long before islet failure.

Metabolic and immunological features of the failing islet-transplanted patient / P. Fiorina, A. Vergani, A. Petrelli, F. D'Addio, L. Monti, R. Abdi, E. Bosi, P. Maffi, A. Secchi. - In: DIABETES CARE. - ISSN 0149-5992. - 31:3(2008), pp. 436-438. [10.2337/dc07-1831]

Metabolic and immunological features of the failing islet-transplanted patient

P. Fiorina
Primo
;
F. D'Addio;E. Bosi;A. Secchi
2008

Abstract

OBJECTIVE -This retrospective study was designed to identify metabolic and immune predictors of early islet allograft failure. RESEARCH DESIGN AND METHODS -We measured several metabolic and immunological markers at the time of pretransplant and several time points posttransplantation in 17 patients with long-term functioning graft (long fx) and 20 patients with short-term functioning graft (short fx). RESULTS -The short fx group showed higher insulin resistance, altered proinsulin processing, lower soluble interleukin-2 receptor (sIL-2r) (marker of T-cell activation), and higher soluble FasL (marker of apoptosis) during the entire follow-up, particularly at time of failure. CONCLUSIONS -Patients who experienced an early failure of islet allograft showed specific metabolic and immunological signs long before islet failure.
lymphocyte gene-expression; diabetic nude-mice; kidney-pancreas; single-donor; improvement; allografts; recipients; rejection; elevation; mellitus
Settore MED/13 - Endocrinologia
Article (author)
File in questo prodotto:
File Dimensione Formato  
436.full.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 143.4 kB
Formato Adobe PDF
143.4 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/499311
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 19
social impact