Background.: Sexual function is altered in patients with type 1 diabetes (T1D) and end-stage renal disease (ESRD), thus affecting quality of life. The present study aimed to analyze sexual function in patients with T1D and ESRD (T1D+ESRD) who received a simultaneous kidney-pancreas (KP) or kidney-alone (KD) transplantation. Methods.: Ten KP, 10 KD, 9 T1D+ESRD patients and 11 healthy control subjects were evaluated according to the following parameters: (1) medical/sexual history and physical examination; (2) International Index of Erectile Function; (3) Beck's inventory for depression; (4) assessment of hormonal profile; (5) quantitative sensory testing of both hand and penile sensory thresholds; and (6) hemodynamic penile assessment. Results.: Controls and KP patients showed a higher rate of self-reported satisfactory erectile function as compared with KD and T1D+ESRD patients. Circulating androgens level resulted lower in both groups of transplanted patients and in patients with T1D+ESRD compared with healthy controls, albeit a relatively better profile was observed in KP. Both transplanted and T1D+ESRD patients showed peripheral hyposensitivity; however, healthy controls and KP showed better penile hemodynamic parameters compared with KD and T1D+ESRD. Conclusions.: Our study demonstrates that sexual function, circulating sex steroids milieu, penile sensitivity, and hemodynamics are near-normalized for the most part in KP transplantation. Further studies are needed to assess the beneficial role and the overall impact of KP transplantation on sexual function in a long-term setting and a larger cohort of patients.
Kidney-pancreas transplantation is associated with near-normal sexual function in uremic type 1 diabetic patients / A. Salonia, F. D'Addio, C. Gremizzi, A. Briganti, F. Dehò, R. Caldara, E. Orsenigo, C. Staudacher, C. Socci, P. Rigatti, A. Secchi, F. Montorsi, P. Fiorina. - In: TRANSPLANTATION. - ISSN 0041-1337. - 92:7(2011), pp. 802-808.
|Titolo:||Kidney-pancreas transplantation is associated with near-normal sexual function in uremic type 1 diabetic patients|
D'ADDIO, FRANCESCA (Secondo)
SECCHI, ANTONIO (Corresponding)
MONTORSI, FRANCESCO (Penultimo)
FIORINA, PAOLO (Ultimo)
|Parole Chiave:||Type 1 diabetes; Sexual function; Hormones; Pancreas transplantation; Kidney transplantation|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
|Data di pubblicazione:||2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/TP.0b013e31822c6eb8|
|Appare nelle tipologie:||01 - Articolo su periodico|