31P-magnetic resonance spectroscopy (31P-MRS) is a non-invasive tool to study high-energy phosphate (HEP) metabolism. We evaluate whether 31P-MRS can detect early changes in kidney HEP metabolism during a 6-month trial with Valsartan. Twenty consecutive stable and normotensive kidney-transplanted patients were enrolled. Nine of them received short-term low-dose Valsartan treatment (80 mg/day) for 6 months, while 11 controls received no medication. Kidney HEP metabolism was evaluated both at baseline and after treatment by 31P-MRS with a 1.5 T system (Gyroscan Intera Master 1.5 MR System; Philips Medical Systems, Best, The Netherlands). Valsartan-treated patients (n = 9) showed a significant increase in β-ATP/Pi ratio, a marker of kidney HEP metabolism (baseline = 1.03 ± 0.08 vs. 6 months = 1.26 ± 0.07, p = 0.03). In contrast, the β-ATP/Pi ratio in the control group (n = 11) did not change (baseline = 0.85 ± 0.10 vs. 6 months = 0.89 ± 0.08, ns). The improvement in the β-ATP/Pi ratio was not associated with a reduction in arterial blood pressure or in urinary albumin excretion. Kidney-localized 31P-MRS can detect early changes in kidney HEP metabolism during a short-term low-dose Valsartan treatment in stable normotensive kidney-transplanted patients.
31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patients / P. Fiorina, R. Bassi, C. Gremizzi, A. Vergani, R. Caldara, A. Mello, A. Del Maschio, F. De Cobelli, G. Perseghin, A. Secchi. - In: ACTA DIABETOLOGICA. - ISSN 0940-5429. - 49:1 suppl.(2012), pp. S133-S139.
|Titolo:||31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patients|
FIORINA, PAOLO (Primo)
PERSEGHIN, GIANLUCA (Penultimo)
|Parole Chiave:||angiotensin receptor antagonists; kidney spectroscopy; kidney transplantation; adult; angiotensin receptor antagonists; female; humans; kidney; kidney failure, chronic; magnetic resonance spectroscopy; male; middle aged; phosphates; tetrazoles; valine; valsartan; kidney transplantation; endocrinology; internal medicine; endocrinology, diabetes and metabolism|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
|Data di pubblicazione:||2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s00592-012-0369-2|
|Appare nelle tipologie:||01 - Articolo su periodico|