Abatacept (cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin fusion protein [CTLA-4-Ig]) is a costimulatory inhibitor that targets B7-1 (CD80). The present report describes five patients who had focal segmental glomerulosclerosis (FSGS) (four with recurrent FSGS after transplantation and one with primary FSGS) and proteinuria with B7-1 immunostaining of podocytes in kidney-biopsy specimens. Abatacept induced partial or complete remissions of proteinuria in these patients, suggesting that B7-1 may be a useful biomarker for the treatment of some glomerulopathies. Our data indicate that abatacept may stabilize β1-integrin activation in podocytes and reduce proteinuria in patients with B7-1-positive glomerular disease.

Abatacept in B7-1-positive proteinuric kidney disease / C. Yu, A. Fornoni, A. Weins, S. Hakroush, D. Maiguel, J. Sageshima, L. Chen, G. Ciancio, M.H. Faridi, D. Behr, K.N. Campbell, J. Chang, H. Chen, J. Oh, C. Faul, M. Amin Arnaout, P. Fiorina, V. Gupta, A. Greka, G.W. Burke III, P. Mundel. - In: NEW ENGLAND JOURNAL OF MEDICINE. - ISSN 0028-4793. - 369:25(2013), pp. 2416-2423.

Abatacept in B7-1-positive proteinuric kidney disease

P. Fiorina;
2013

Abstract

Abatacept (cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin fusion protein [CTLA-4-Ig]) is a costimulatory inhibitor that targets B7-1 (CD80). The present report describes five patients who had focal segmental glomerulosclerosis (FSGS) (four with recurrent FSGS after transplantation and one with primary FSGS) and proteinuria with B7-1 immunostaining of podocytes in kidney-biopsy specimens. Abatacept induced partial or complete remissions of proteinuria in these patients, suggesting that B7-1 may be a useful biomarker for the treatment of some glomerulopathies. Our data indicate that abatacept may stabilize β1-integrin activation in podocytes and reduce proteinuria in patients with B7-1-positive glomerular disease.
Abatacept; Adolescent; Adult; Antigens, CD80; Biomarkers; Child; Female; Glomerulosclerosis, Focal Segmental; Humans; Immunoconjugates; Male; Podocytes; Proteinuria; Young Adult; Medicine (all)
Settore MED/13 - Endocrinologia
Article (author)
File in questo prodotto:
File Dimensione Formato  
nejmoa1304572.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 712.47 kB
Formato Adobe PDF
712.47 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/499216
Citazioni
  • ???jsp.display-item.citation.pmc??? 127
  • Scopus 281
  • ???jsp.display-item.citation.isi??? 243
social impact