Cyclin B is a central regulator of transition from the G2 phase of the cell cycle to mitosis. In mammalian cells two B-type cyclins have been characterised, cyclin B1 and B2. Both are expressed with a maximum in G2 and their synthesis is mainly regulated on the transcriptional level. We show that a single cell cycle genes homology region, lacking a functional cell cycle-dependent element in tandem with it, contributes most of the cell cycle-dependent transcription from the cyclin B1 promoter. The coactivator p300 binds to the cyclin B1 promoter and synergises with the transcription factor NF-Y in activating transcription of cyclin B1.
|Titolo:||Cyclin B1 transcription is enhanced by the p300 coactivator and regulated during the cell cycle by a CHR-dependent repression mechanism|
MANTOVANI, ROBERTO (Penultimo)
|Parole Chiave:||Cancer; Cell cycle-dependent element/cell cycle genes homology region; Cell cycle-dependent transcription; Cell division cycle; Chromatin immunoprecipitation; Histone acetyltransferase|
|Settore Scientifico Disciplinare:||Settore BIO/18 - Genetica|
|Data di pubblicazione:||2003|
|Digital Object Identifier (DOI):||10.1016/S0014-5793(03)00028-0|
|Appare nelle tipologie:||01 - Articolo su periodico|