Cyclin B is a central regulator of transition from the G2 phase of the cell cycle to mitosis. In mammalian cells two B-type cyclins have been characterised, cyclin B1 and B2. Both are expressed with a maximum in G2 and their synthesis is mainly regulated on the transcriptional level. We show that a single cell cycle genes homology region, lacking a functional cell cycle-dependent element in tandem with it, contributes most of the cell cycle-dependent transcription from the cyclin B1 promoter. The coactivator p300 binds to the cyclin B1 promoter and synergises with the transcription factor NF-Y in activating transcription of cyclin B1.
Titolo: | Cyclin B1 transcription is enhanced by the p300 coactivator and regulated during the cell cycle by a CHR-dependent repression mechanism |
Autori: | MANTOVANI, ROBERTO (Penultimo) |
Parole Chiave: | Cancer; Cell cycle-dependent element/cell cycle genes homology region; Cell cycle-dependent transcription; Cell division cycle; Chromatin immunoprecipitation; Histone acetyltransferase |
Settore Scientifico Disciplinare: | Settore BIO/18 - Genetica |
Data di pubblicazione: | 2003 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | 10.1016/S0014-5793(03)00028-0 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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