A novel potassium oxalate-based hydrogel is proposed for treating dentin hypersensitivity and this study evaluates its in vitro performance as a remineralizing, desensitizing agent. Etched disks of human dentin were treated for 10 or 20 min using the test hydrogel, to mimic a professional application with dental mouth guards. Dentin disks were evaluated in terms of permeability indexes in a fluid-filled system, the surface morphology was assessed by scanning electron microscopy, and the structural properties were studied using X-ray diffraction analysis. The potassium oxalate hydrogel significantly reduced dentin permeability, in a time-dependent manner, and occluded most of the patent dentinal tubules via crystal precipitation, forming a remineralized layer. After hydrogel treatments, an acid solution (pH 4.2) was applied to the disks for 30 s, or 1, 2, or 5 min, in order to reproduce a plaque-like oral acidity, and further analysis showed a good resistance of the remineralized layer to the acid challenge. The potassium oxalate-based hydrogel showed a better performance over commercially available products and artificial saliva, appearing a promising candidate for the treatment of dentin hypersensitivity.
In vitro efficacy of a novel potassium oxalate hydrogel for dentin hypersensitivity / E.M. Varoni, T. Zuccheri, A. Carletta, B. Palazzo, A. Cochis, M. Colonna, L. Rimondini. - In: EUROPEAN JOURNAL OF ORAL SCIENCES. - ISSN 0909-8836. - 125:2(2017), pp. 151-159.
|Titolo:||In vitro efficacy of a novel potassium oxalate hydrogel for dentin hypersensitivity|
VARONI, ELENA MARIA (Primo)
|Parole Chiave:||dentin desensitizing agents; dentinal fluid; tooth remineralization; dentistry (all)|
|Settore Scientifico Disciplinare:||Settore MED/28 - Malattie Odontostomatologiche|
|Data di pubblicazione:||2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/eos.12334|
|Appare nelle tipologie:||01 - Articolo su periodico|
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