Oxalate degrading enzymes have a number of potential applications, including medical diagnosis and treatments for hyperoxaluria and other oxalate-related diseases, the production of transgenic plants for human consumption, and bioremediation of the environment. This review seeks to provide a brief overview of current knowledge regarding the major classes of enzymes and related proteins that are employed in plants, fungi, and bacteria to convert oxalate into CO 2 and/or formate. Not only do these enzymes employ intriguing chemical strategies for cleaving the chemically unreactive CC bond in oxalate, but they also offer the prospect of providing new insights into the molecular processes that underpin the evolution of biological catalysts.
The enzymes of oxalate metabolism : Unexpected structures and mechanisms / D. Svedružić, S. Jónsson, C.G. Toyota, L.A. Reinhardt, S. Ricagno, Y. Lindqvist, N.G.J. Richards. - In: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. - ISSN 0003-9861. - 433:1(2005 Jan), pp. 176-192.
The enzymes of oxalate metabolism : Unexpected structures and mechanisms
S. Ricagno;
2005
Abstract
Oxalate degrading enzymes have a number of potential applications, including medical diagnosis and treatments for hyperoxaluria and other oxalate-related diseases, the production of transgenic plants for human consumption, and bioremediation of the environment. This review seeks to provide a brief overview of current knowledge regarding the major classes of enzymes and related proteins that are employed in plants, fungi, and bacteria to convert oxalate into CO 2 and/or formate. Not only do these enzymes employ intriguing chemical strategies for cleaving the chemically unreactive CC bond in oxalate, but they also offer the prospect of providing new insights into the molecular processes that underpin the evolution of biological catalysts.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
