Objectives: To test 3T proton magnetic resonance spectroscopy (1H-MRS) for breast mass lesions. Methods: Patients with BI-RADS 4–5 lesions at mammography/ultrasound were prospectively enrolled. After contrast-enhanced breast MRI, single-voxel MRS (point-resolved volume selection, PRESS); pencil-beam shimming; volume of interest 1 cm3; TR/TE = 3000/135 ms) was performed. Spectra were considered reliable if the full width at half maximum (FWHM) of the water peak was ≤45 Hz. A signal-to-noise ratio of the total choline (tCho) peak at 3.21 ppm ≥2 was used as cutoff for malignancy. All lesions underwent needle sampling. Final pathology was available for all malignant lesions; for benign lesions the reference standard was final pathology or at least 1-year negative follow-up. Results: Reliable spectra were obtained in 115/127 lesions (91%), with a mean FWHM of 32.4 Hz (range 8–45 Hz). A tCho peak SNR ≥2 was detected in 66 malignant lesions (62 invasive cancers; 4 ductal carcinoma in situ) and in 3 benign lesions. Excluding lesions located ≤1 cm from the skin (n = 3) or pectoral muscle (n = 11), sensitivity was 65/73 [89%, 95% confidence interval (CI): 80–95%], and specificity 25/28 (89%) (95% CI: 72–98%). Considering only invasive cancers, sensitivity reached 61/68 (90%, 95% CI: 81–96%). MRS additional time was 8 min. Conclusions: When lesions close to the skin or pectoral muscle are excluded, 3T 1H-MRS of mass lesions ≥1 cm showed a high diagnostic performance, however, insufficient to avoid needle biopsy.

1H-MR spectroscopy of suspicious breast mass lesions at 3T: a clinical experience / S. Montemezzi, C. Cavedon, L. Camera, G. Meliadò, F. Caumo, I. Baglio, F. Sardanelli. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - 122:3(2017), pp. 161-170.

1H-MR spectroscopy of suspicious breast mass lesions at 3T: a clinical experience

F. Sardanelli
2017

Abstract

Objectives: To test 3T proton magnetic resonance spectroscopy (1H-MRS) for breast mass lesions. Methods: Patients with BI-RADS 4–5 lesions at mammography/ultrasound were prospectively enrolled. After contrast-enhanced breast MRI, single-voxel MRS (point-resolved volume selection, PRESS); pencil-beam shimming; volume of interest 1 cm3; TR/TE = 3000/135 ms) was performed. Spectra were considered reliable if the full width at half maximum (FWHM) of the water peak was ≤45 Hz. A signal-to-noise ratio of the total choline (tCho) peak at 3.21 ppm ≥2 was used as cutoff for malignancy. All lesions underwent needle sampling. Final pathology was available for all malignant lesions; for benign lesions the reference standard was final pathology or at least 1-year negative follow-up. Results: Reliable spectra were obtained in 115/127 lesions (91%), with a mean FWHM of 32.4 Hz (range 8–45 Hz). A tCho peak SNR ≥2 was detected in 66 malignant lesions (62 invasive cancers; 4 ductal carcinoma in situ) and in 3 benign lesions. Excluding lesions located ≤1 cm from the skin (n = 3) or pectoral muscle (n = 11), sensitivity was 65/73 [89%, 95% confidence interval (CI): 80–95%], and specificity 25/28 (89%) (95% CI: 72–98%). Considering only invasive cancers, sensitivity reached 61/68 (90%, 95% CI: 81–96%). MRS additional time was 8 min. Conclusions: When lesions close to the skin or pectoral muscle are excluded, 3T 1H-MRS of mass lesions ≥1 cm showed a high diagnostic performance, however, insufficient to avoid needle biopsy.
Breast; Breast cancer; Magnetic resonance imaging; Proton magnetic resonance spectroscopy (1H-MRS); Adult; Aged; Aged, 80 and over; Biopsy, Fine-Needle; Body Water; Breast; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Choline; Confidence Intervals; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Pectoralis Muscles; Prospective Studies; Sensitivity and Specificity; Signal-To-Noise Ratio; Ultrasonography, Mammary; Proton Magnetic Resonance Spectroscopy; Radiology, Nuclear Medicine and Imaging
Settore MED/36 - Diagnostica per Immagini e Radioterapia
http://link.springer.com/journal/11547
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/491798
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