In this work we compared, in the same immunization schedule in mice, two vaccine candidates against Dengue-4 based on the envelope protein domain III and the carrier P64k. Their molecular and antigenic features, immunogenicity and protective capacity in the viral encephalitis murine model are assessed. Our study endorses the strategy of using both sites of inclusion within the same P64k molecule, in order to enhance the immunogenicity of protein fragments.

Comparative immunogenicity and protective capacity of two Dengue-4 vaccine candidates based on P64k-envelope domain III / L. Lazo, L. Gil, A. Zulueta, I. Valdés, Y. Soria, Y. Romero, G. Guillén, L. Hermida. - In: BIOTECNOLOGIA APLICADA. - ISSN 0864-4551. - 26:4(2009), pp. 333-337.

Comparative immunogenicity and protective capacity of two Dengue-4 vaccine candidates based on P64k-envelope domain III

A. Zulueta;
2009

Abstract

In this work we compared, in the same immunization schedule in mice, two vaccine candidates against Dengue-4 based on the envelope protein domain III and the carrier P64k. Their molecular and antigenic features, immunogenicity and protective capacity in the viral encephalitis murine model are assessed. Our study endorses the strategy of using both sites of inclusion within the same P64k molecule, in order to enhance the immunogenicity of protein fragments.
Carrier; Dengue; P64k; Vaccine; Applied Microbiology and Biotechnology; Biotechnology
Settore BIO/10 - Biochimica
Settore BIO/11 - Biologia Molecolare
Settore BIO/19 - Microbiologia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/491438
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