Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) are emerging problems in several countries. These infections require long and expensive treatment regimens. Recently, 2 new drugs, bedaquiline and delamanid, have been approved in several countries for use in adults with severe, difficult-to-treat MDR-TB, and it has been suggested that they could also be administered to children with MDR-TB and limited treatment options. However, no study has been completed on their efficacy.

Efficacy, safety, and tolerability of a 24-month treatment regimen including delamanid in a child with extensively drug-resistant tuberculosis : a case report and review of the literature / S. Esposito, S. Bosis, M. Tadolini, S. Bianchini, G.B. Migliori, N. Principi. - In: MEDICINE. - ISSN 0025-7974. - 95:46(2016 Nov), pp. e5347.1-e5347.4.

Efficacy, safety, and tolerability of a 24-month treatment regimen including delamanid in a child with extensively drug-resistant tuberculosis : a case report and review of the literature

S. Esposito;S. Bosis;S. Bianchini;N. Principi
2016-11

Abstract

Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) are emerging problems in several countries. These infections require long and expensive treatment regimens. Recently, 2 new drugs, bedaquiline and delamanid, have been approved in several countries for use in adults with severe, difficult-to-treat MDR-TB, and it has been suggested that they could also be administered to children with MDR-TB and limited treatment options. However, no study has been completed on their efficacy.
Antitubercular Agents; Child; Drug Therapy, Combination; Extensively Drug-Resistant Tuberculosis; Humans; Italy; Male; Nitroimidazoles; Oxazoles
Settore MED/38 - Pediatria Generale e Specialistica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/490712
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