Background: Exertional oscillatory ventilation (EOV) in heart failure may potentiate the negative effects of low cardiac output and high ventilation on exercise performance. We hypothesized that the presence of EOV might, per se, influence exercise capacity as evaluated by maximal cardiopulmonary exercise test. Methods and results: We identified 78 severe chronic heart failure patient pairs with and without EOV. Patients were matched for sex, age and peak oxygen consumption (VO2). Patients with EOV showed, for the same peak VO2, a lower workload (WL) at peak (ΔWatts=5.8±23.0, P=0.027), a less efficient ventilation (higher VE/VCO2 slope: 38.0±8.3 vs. 32.8±6.3, P<0.001), lower peak exercise tidal volume (1.49±0.36 L vs. 1.61±0.46 L, P=0.015) and higher peak respiratory rate (34±7/min vs. 31±6/min, P=0.002). In 33 patients, EOV disappeared during exercise, whereas in 45 patients EOV persisted. Fifty percent of EOV disappearing patients had an increase in the VO2/WL relationship after EOV regression, consistent with a more efficient oxygen delivery to muscles. No cardiopulmonary exercise test parameter was associated with the different behaviour of VO2/WL. Conclusion: The presence of EOV negatively influences exercise performance of chronic heart failure patients likely because of an increased cost of breathing. EOV disappearance during exercise is associated with a more efficient oxygen delivery in several cases.

Influence of exertional oscillatory ventilation on exercise performance in heart failure / J.P. Schmid, A. Apostolo, L. Antonioli, G. Cattadori, M. Zurek, M. Contini, P. Agostoni. - In: EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION. - ISSN 1741-8267. - 15:6(2008 Dec), pp. 688-692.

Influence of exertional oscillatory ventilation on exercise performance in heart failure

L. Antonioli;P. Agostoni
Ultimo
2008-12

Abstract

Background: Exertional oscillatory ventilation (EOV) in heart failure may potentiate the negative effects of low cardiac output and high ventilation on exercise performance. We hypothesized that the presence of EOV might, per se, influence exercise capacity as evaluated by maximal cardiopulmonary exercise test. Methods and results: We identified 78 severe chronic heart failure patient pairs with and without EOV. Patients were matched for sex, age and peak oxygen consumption (VO2). Patients with EOV showed, for the same peak VO2, a lower workload (WL) at peak (ΔWatts=5.8±23.0, P=0.027), a less efficient ventilation (higher VE/VCO2 slope: 38.0±8.3 vs. 32.8±6.3, P<0.001), lower peak exercise tidal volume (1.49±0.36 L vs. 1.61±0.46 L, P=0.015) and higher peak respiratory rate (34±7/min vs. 31±6/min, P=0.002). In 33 patients, EOV disappeared during exercise, whereas in 45 patients EOV persisted. Fifty percent of EOV disappearing patients had an increase in the VO2/WL relationship after EOV regression, consistent with a more efficient oxygen delivery to muscles. No cardiopulmonary exercise test parameter was associated with the different behaviour of VO2/WL. Conclusion: The presence of EOV negatively influences exercise performance of chronic heart failure patients likely because of an increased cost of breathing. EOV disappearance during exercise is associated with a more efficient oxygen delivery in several cases.
Cardiopulmonary exercise test; Exercise capacity; Oxygen consumption; Periodic breathing
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/49009
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 13
  • ???jsp.display-item.citation.isi??? 16
social impact